Abstract
The aim of this study was to elucidate the clinical usefulness of scatter correction with an artificial neural network (ANN) in 99mTc and 123I dual-isotope SPECT. Methods: Two algorithms for ANN scatter correction were tested: ANN-10 and ANN-3 employing 10 and 3 energy windows for data acquisition, respectively. Three patients underwent myocardial or brain SPECT with one of the following combinations of radiopharmaceuticals administered: 99mTc-tetrofosmin and 123I- metaiodobenzylguanidine (MIBG), 99mTc-methoxyisobutylisonitrile (MIBI) and 123I-beta-methylparaiodophenyl-pentadecanoic acid (BMIPP), or 99mTc-ethyl-cistainate dimmer (ECD) and 123I- iomazenil. The patients were also referred for single-isotope imaging incorporating conventional triple-energy window (TEW) scatter correction. Crosstalk- and scatter-corrected 99mTc- and 123I-SPECT images in dual-isotope acquisition with ANN were compared with those in single-isotope acquisition. Results: The ANN method well separated 123I and 99mTc primary photons. Although ANN-10 yielded images of poor quality, ANN-3 offered comparable image quality with the single-isotope scan without significant increase of acquisition time. Conclusion: The proposed method is clinically useful because it provides various combinations of information without anatomical misregistration with one acquisition.
| Original language | English |
|---|---|
| Pages (from-to) | 25-32 |
| Number of pages | 8 |
| Journal | Annals of Nuclear Medicine |
| Volume | 21 |
| Issue number | 1 |
| Publication status | Published - 2007 |
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Keywords
- Artificial neural network
- Brain SPECT
- Dual-isotope SPECT
- Myocardial SPECT
- Scatter correction
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Scatter correction based on an artificial neural network for 99mTc and 123I dual-isotope SPECT in myocardial and brain imaging. / Bai, Jingming; Hashimoto, Jun; Ogawa, Koichi; Nakahara, Tadaki; Suzuki, Takayuki; Kubo, Atsushi.
In: Annals of Nuclear Medicine, Vol. 21, No. 1, 2007, p. 25-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Scatter correction based on an artificial neural network for 99mTc and 123I dual-isotope SPECT in myocardial and brain imaging
AU - Bai, Jingming
AU - Hashimoto, Jun
AU - Ogawa, Koichi
AU - Nakahara, Tadaki
AU - Suzuki, Takayuki
AU - Kubo, Atsushi
PY - 2007
Y1 - 2007
N2 - The aim of this study was to elucidate the clinical usefulness of scatter correction with an artificial neural network (ANN) in 99mTc and 123I dual-isotope SPECT. Methods: Two algorithms for ANN scatter correction were tested: ANN-10 and ANN-3 employing 10 and 3 energy windows for data acquisition, respectively. Three patients underwent myocardial or brain SPECT with one of the following combinations of radiopharmaceuticals administered: 99mTc-tetrofosmin and 123I- metaiodobenzylguanidine (MIBG), 99mTc-methoxyisobutylisonitrile (MIBI) and 123I-beta-methylparaiodophenyl-pentadecanoic acid (BMIPP), or 99mTc-ethyl-cistainate dimmer (ECD) and 123I- iomazenil. The patients were also referred for single-isotope imaging incorporating conventional triple-energy window (TEW) scatter correction. Crosstalk- and scatter-corrected 99mTc- and 123I-SPECT images in dual-isotope acquisition with ANN were compared with those in single-isotope acquisition. Results: The ANN method well separated 123I and 99mTc primary photons. Although ANN-10 yielded images of poor quality, ANN-3 offered comparable image quality with the single-isotope scan without significant increase of acquisition time. Conclusion: The proposed method is clinically useful because it provides various combinations of information without anatomical misregistration with one acquisition.
AB - The aim of this study was to elucidate the clinical usefulness of scatter correction with an artificial neural network (ANN) in 99mTc and 123I dual-isotope SPECT. Methods: Two algorithms for ANN scatter correction were tested: ANN-10 and ANN-3 employing 10 and 3 energy windows for data acquisition, respectively. Three patients underwent myocardial or brain SPECT with one of the following combinations of radiopharmaceuticals administered: 99mTc-tetrofosmin and 123I- metaiodobenzylguanidine (MIBG), 99mTc-methoxyisobutylisonitrile (MIBI) and 123I-beta-methylparaiodophenyl-pentadecanoic acid (BMIPP), or 99mTc-ethyl-cistainate dimmer (ECD) and 123I- iomazenil. The patients were also referred for single-isotope imaging incorporating conventional triple-energy window (TEW) scatter correction. Crosstalk- and scatter-corrected 99mTc- and 123I-SPECT images in dual-isotope acquisition with ANN were compared with those in single-isotope acquisition. Results: The ANN method well separated 123I and 99mTc primary photons. Although ANN-10 yielded images of poor quality, ANN-3 offered comparable image quality with the single-isotope scan without significant increase of acquisition time. Conclusion: The proposed method is clinically useful because it provides various combinations of information without anatomical misregistration with one acquisition.
KW - Artificial neural network
KW - Brain SPECT
KW - Dual-isotope SPECT
KW - Myocardial SPECT
KW - Scatter correction
UR - http://www.scopus.com/inward/record.url?scp=33847130108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847130108&partnerID=8YFLogxK
M3 - Article
C2 - 17373333
AN - SCOPUS:33847130108
VL - 21
SP - 25
EP - 32
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
SN - 0914-7187
IS - 1
ER -