SCE induction in human lymphocytes by combined treatment with aniline and norharman

S. Takehisa, Nobuhiro Kanaya

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In human blood lymphocytes, aniline was unable to induce an increase of SCEs in vitro with or without metabolic activation by S9 mix. p-Aminophenol, one of the C-hydroxylation metabolites of aniline in the body, however, increased the SCE frequencies of lymphocytes at a concentration of 10-4 M. The addition of norharman to aniline plus S9 mix increased the SCE frequencies. This increase, however, was due to the SCE-inducing activity of norharman. These data show that the addition of norharman, which enhances the sensitivity of the Salmonella/microsome test, does not produce an enhancement of the sensitivity of the SCE test.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalMutation Research/Genetic Toxicology
Volume101
Issue number2
DOIs
Publication statusPublished - 1982

Fingerprint

norharman
Lymphocytes
Hydroxylation
Salmonella
Metabolites
Microsomes
Blood
Chemical activation
aniline

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

SCE induction in human lymphocytes by combined treatment with aniline and norharman. / Takehisa, S.; Kanaya, Nobuhiro.

In: Mutation Research/Genetic Toxicology, Vol. 101, No. 2, 1982, p. 165-172.

Research output: Contribution to journalArticle

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