SCE induction in human lymphocytes by combined treatment with aniline and norharman

S. Takehisa, Nobuhiro Kanaya

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19 Citations (Scopus)


In human blood lymphocytes, aniline was unable to induce an increase of SCEs in vitro with or without metabolic activation by S9 mix. p-Aminophenol, one of the C-hydroxylation metabolites of aniline in the body, however, increased the SCE frequencies of lymphocytes at a concentration of 10-4 M. The addition of norharman to aniline plus S9 mix increased the SCE frequencies. This increase, however, was due to the SCE-inducing activity of norharman. These data show that the addition of norharman, which enhances the sensitivity of the Salmonella/microsome test, does not produce an enhancement of the sensitivity of the SCE test.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalMutation Research/Genetic Toxicology
Issue number2
Publication statusPublished - 1982


ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

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