Scheduled second-look endoscopy is not recommended after endoscopic submucosal dissection for gastric neoplasms (the SAFE trial): A multicentre prospective randomised controlled non-inferiority trial

Satoshi Mochizuki, Noriya Uedo, Ichiro Oda, Kazuhiro Kaneko, Yorimasa Yamamoto, Takeshi Yamashina, Haruhisa Suzuki, Shinya Kodashima, Tomonori Yano, Nobutake Yamamichi, Osamu Goto, Takeshi Shimamoto, Mitsuhiro Fujishiro, Kazuhiko Koike

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Abstract

Objective: To clarify the effectiveness of second-look endoscopy (SLE) at preventing bleeding after gastric endoscopic submucosal dissection (ESD). Design: A multicentre prospective randomised controlled non-inferiority trial was conducted at five referral institutions across Japan. Patients with a solitary gastric neoplasm were enrolled. Exclusion criteria were previous oesophagogastric surgery or radiation therapy; perforation and the administration of antithrombotics, steroids or non-steroidal anti-inflammatory drugs. Patients were assigned to the SLE group or the non-SLE group by a computer-generated random sequence after ESD and were treated perioperatively with a proton pump inhibitor. SLE was performed one day after ESD. The primary endpoint was post-ESD bleeding, defined as an endoscopically proven haemorrhage. The trial had the power to detect a non-inferiority criterion of 7% between the groups. Results: From February 2012 to February 2013, 130 and 132 patients were assigned to the SLE and the non-SLE groups, respectively. All patients were included in the intention-to-treat analysis of the primary endpoint. Post-ESD bleeding occurred in seven patients with (5.4%) SLE and five patients with (3.8%) non-SLE (risk difference -1.6% (95% CI -6.7 to 3.5); pnon-inferiority<0.001), meeting the non-inferiority criterion. All 12 patients with post-ESD bleeding and one patient with a delayed perforation were successfully managed with conservative treatment. Conclusions: SLE after gastric ESD is not routinely recommended because it does not contribute to the prevention of post-ESD bleeding for patients with an average bleeding risk.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalGut
Volume64
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

ASJC Scopus subject areas

  • Gastroenterology

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    Mochizuki, S., Uedo, N., Oda, I., Kaneko, K., Yamamoto, Y., Yamashina, T., Suzuki, H., Kodashima, S., Yano, T., Yamamichi, N., Goto, O., Shimamoto, T., Fujishiro, M., & Koike, K. (2015). Scheduled second-look endoscopy is not recommended after endoscopic submucosal dissection for gastric neoplasms (the SAFE trial): A multicentre prospective randomised controlled non-inferiority trial. Gut, 64(3), 397-405. https://doi.org/10.1136/gutjnl-2014-307552