School-age children and adolescents suspected of having been to be infected with pertussis in Japan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI; 56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI; 61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI; 40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.

Original languageEnglish
Pages (from-to)2910-2915
Number of pages6
JournalVaccine
Volume36
Issue number20
DOIs
Publication statusPublished - 2018 May 11

Fingerprint

whooping cough
Whooping Cough
Japan
pertussis toxin
antibodies
vaccines
Pertussis Toxin
Antibodies
Diphtheria-Tetanus-acellular Pertussis Vaccines
toxoids
elementary schools
Acellular Vaccines
tetanus
Diphtheria Toxoid
Pertussis Vaccine
Tetanus Toxoid
Asymptomatic Infections
Adaptive Immunity
households
deterioration

Keywords

  • Acellular pertussis vaccine
  • FHA antibody
  • Pertussis
  • PT antibody
  • Sero-epidemiology

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

School-age children and adolescents suspected of having been to be infected with pertussis in Japan. / Yasui, Yosuke; Mitsui, Toshikatsu; Nishimura, Tomoyasu; Uchida, Keiko; Inokuchi, Mikako; Mori, Masaaki; Tokumura, Mitsuaki; Nakayama, Tetsuo.

In: Vaccine, Vol. 36, No. 20, 11.05.2018, p. 2910-2915.

Research output: Contribution to journalArticle

@article{2ca149ab719043f0890ad6a5a74da3af,
title = "School-age children and adolescents suspected of having been to be infected with pertussis in Japan",
abstract = "Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90{\%}, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0{\%}. 95{\%}CI; 56.0–63.9{\%}) in 2014 and 18–19 years (73.0{\%}. 95{\%}CI; 61.4–82.6{\%}) in 2013, compared with 6–7 years (47.1{\%}. 95{\%}CI; 40.7–53.6{\%}). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95{\%}CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95{\%}CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95{\%}CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.",
keywords = "Acellular pertussis vaccine, FHA antibody, Pertussis, PT antibody, Sero-epidemiology",
author = "Yosuke Yasui and Toshikatsu Mitsui and Tomoyasu Nishimura and Keiko Uchida and Mikako Inokuchi and Masaaki Mori and Mitsuaki Tokumura and Tetsuo Nakayama",
year = "2018",
month = "5",
day = "11",
doi = "10.1016/j.vaccine.2018.01.048",
language = "English",
volume = "36",
pages = "2910--2915",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "20",

}

TY - JOUR

T1 - School-age children and adolescents suspected of having been to be infected with pertussis in Japan

AU - Yasui, Yosuke

AU - Mitsui, Toshikatsu

AU - Nishimura, Tomoyasu

AU - Uchida, Keiko

AU - Inokuchi, Mikako

AU - Mori, Masaaki

AU - Tokumura, Mitsuaki

AU - Nakayama, Tetsuo

PY - 2018/5/11

Y1 - 2018/5/11

N2 - Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI; 56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI; 61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI; 40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.

AB - Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI; 56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI; 61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI; 40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.

KW - Acellular pertussis vaccine

KW - FHA antibody

KW - Pertussis

KW - PT antibody

KW - Sero-epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85046417314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046417314&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2018.01.048

DO - 10.1016/j.vaccine.2018.01.048

M3 - Article

VL - 36

SP - 2910

EP - 2915

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 20

ER -