Abstract
Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI; 56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI; 61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI; 40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.
| Original language | English |
|---|---|
| Pages (from-to) | 2910-2915 |
| Number of pages | 6 |
| Journal | Vaccine |
| Volume | 36 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2018 May 11 |
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Keywords
- Acellular pertussis vaccine
- FHA antibody
- Pertussis
- PT antibody
- Sero-epidemiology
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
School-age children and adolescents suspected of having been to be infected with pertussis in Japan. / Yasui, Yosuke; Mitsui, Toshikatsu; Nishimura, Tomoyasu; Uchida, Keiko; Inokuchi, Mikako; Mori, Masaaki; Tokumura, Mitsuaki; Nakayama, Tetsuo.
In: Vaccine, Vol. 36, No. 20, 11.05.2018, p. 2910-2915.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - School-age children and adolescents suspected of having been to be infected with pertussis in Japan
AU - Yasui, Yosuke
AU - Mitsui, Toshikatsu
AU - Nishimura, Tomoyasu
AU - Uchida, Keiko
AU - Inokuchi, Mikako
AU - Mori, Masaaki
AU - Tokumura, Mitsuaki
AU - Nakayama, Tetsuo
PY - 2018/5/11
Y1 - 2018/5/11
N2 - Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI; 56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI; 61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI; 40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.
AB - Many countries including Japan have adapted acellular pertussis vaccines combined with diphtheria and tetanus toxoids (DTaP). DTaP vaccine coverage is approximately >90%, but pertussis re-emergence has been observed since 2000 in Japan. In the present study, anti-pertussis antibodies were investigated among school-age children and adolescents from 2013 to 2015. The positive rate of anti-pertussis toxin (PT) antibodies was higher among children aged 12–13 years (60.0%. 95%CI; 56.0–63.9%) in 2014 and 18–19 years (73.0%. 95%CI; 61.4–82.6%) in 2013, compared with 6–7 years (47.1%. 95%CI; 40.7–53.6%). The mean PT antibody titer was higher among children aged 12–13 years (23.8 EU/ml. 95%CI; 21.9–25.8) in 2014 and 18–19 years (29.3 EU/ml. 95%CI; 23.0–35.6) in 2013, compared with 6–7 years (18.3 EU/ml. 95%CI; 15.5–21.2). Distributions of pertussis antibodies and mean titers at their same grade of school-age were similar from 2013 to 2015. Although school-age children were immunized with 4 doses of DTaP, the data suggested the decay of vaccine-acquired immunity and possibility of asymptomatic infection in school age, indicating the additional DTaP vaccination before the entry of elementary school, preventing household contact.
KW - Acellular pertussis vaccine
KW - FHA antibody
KW - Pertussis
KW - PT antibody
KW - Sero-epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85046417314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046417314&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2018.01.048
DO - 10.1016/j.vaccine.2018.01.048
M3 - Article
C2 - 29609967
AN - SCOPUS:85046417314
VL - 36
SP - 2910
EP - 2915
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 20
ER -