Scientific advances in lung cancer 2015

Anne S. Tsao, Giorgio V. Scagliotti, Paul A. Bunn, David P. Carbone, Graham W. Warren, Chunxue Bai, Harry J. De Koning, A. Uraujh Yousaf-Khan, Annette McWilliams, Ming Sound Tsao, Prasad S. Adusumilli, Ramón Rami-Porta, Hisao Asamura, Paul E. Van Schil, Gail E. Darling, Suresh S. Ramalingam, Daniel R. Gomez, Kenneth E. Rosenzweig, Stefan Zimmermann, Solange PetersSai Hong Ignatius Ou, Thanyanan Reungwetwattana, Pasi A. Jänne, Tony S. Mok, Heather A. Wakelee, Robert Pirker, Julien Mazières, Julie R. Brahmer, Yang Zhou, Roy S. Herbst, Vassiliki A. Papadimitrakopoulou, Mary W. Redman, Murry W. Wynes, David R. Gandara, Ronan J. Kelly, Fred R. Hirsch, Harvey I. Pass

Research output: Contribution to journalReview article

121 Citations (Scopus)

Abstract

Lung cancer continues to be a major global health problem; the disease is diagnosed in more than 1.6 million new patients each year. However, significant progress is underway in both the prevention and treatment of lung cancer. Lung cancer therapy has now emerged as a "role model" for precision cancer medicine, with several important therapeutic breakthroughs occurring during 2015. These advances have occurred primarily in the immunotherapy field and in treatments directed against tumors harboring specific oncogenic drivers. Our knowledge about molecular mechanisms for oncogene-driven tumors and about resistance to targeted therapies has increased quickly over the past year. As a result, several regulatory approvals of new agents that significantly improve survival and quality of life for patients with lung cancer who have advanced disease have occurred. The International Association for the Study of Lung Cancer has gathered experts in different areas of lung cancer research and management to summarize the most significant scientific advancements related to prevention and therapy of lung cancer during the past year.

Original languageEnglish
Pages (from-to)613-638
Number of pages26
JournalJournal of Thoracic Oncology
Volume11
Issue number5
DOIs
Publication statusPublished - 2016

Keywords

  • Adjuvant chemotherapy
  • Biomarkers
  • Cancer prevention
  • Gene mutations
  • Immunotherapy
  • Lung cancer
  • Master protocols
  • Pathology
  • Radiotherapy
  • Screening
  • Smoking cessation
  • Staging
  • Surgery
  • Targeted therapy
  • Value of therapy

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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  • Cite this

    Tsao, A. S., Scagliotti, G. V., Bunn, P. A., Carbone, D. P., Warren, G. W., Bai, C., De Koning, H. J., Uraujh Yousaf-Khan, A., McWilliams, A., Tsao, M. S., Adusumilli, P. S., Rami-Porta, R., Asamura, H., Van Schil, P. E., Darling, G. E., Ramalingam, S. S., Gomez, D. R., Rosenzweig, K. E., Zimmermann, S., ... Pass, H. I. (2016). Scientific advances in lung cancer 2015. Journal of Thoracic Oncology, 11(5), 613-638. https://doi.org/10.1016/j.jtho.2016.03.012