Abstract
We conducted a cohort analytic study to determine whether an unexplained increase in maternal serum alpha-fetoprotein (MSAFP) or human chorionic gonadotropin (MShCG) is effective in screening for adverse perinatal outcomes. MSAFP and MShCG levels were measured in 1,097 consecutive pregnant women in whom gestation was dated by ultrasonography and who later delivered a single infant. Patients with high MSAFP or MShCG had a much higher risk of low birth weight, intrauterine growth retardation and fetal death. But a screening test with MShCG for predicting preterm birth, low birth weight and intrauterine growth retardation had an approximately twice higher sensitivity than that with MSAFP. A combination of MSAFP and MShCG had little effect on the sensitivity. We concluded that a screening test with MShCG alone might be useful in predicting adverse perinatal outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 1229-1233 |
| Number of pages | 5 |
| Journal | Acta Obstetrica et Gynaecologica Japonica |
| Volume | 46 |
| Issue number | 11 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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Keywords
- adverse perinatal outcome
- alpha-fetoprotein
- human chorionic gonadotropin
- maternal serum
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Screening for adverse perinatal outcome by biomarkers in maternal serum; a comparison of elevated maternal serum alpha-fetoprotein versus human chorionic gonadotropin. / Tanaka, Mamoru; Natori, M.; Ishimoto, H.; Gohda, N.; Kiyokawa, K.; Yamauchi, J.; Miyazaki, T.; Kobayashi, T.; Nozawa, S.
In: Acta Obstetrica et Gynaecologica Japonica, Vol. 46, No. 11, 1994, p. 1229-1233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Screening for adverse perinatal outcome by biomarkers in maternal serum; a comparison of elevated maternal serum alpha-fetoprotein versus human chorionic gonadotropin
AU - Tanaka, Mamoru
AU - Natori, M.
AU - Ishimoto, H.
AU - Gohda, N.
AU - Kiyokawa, K.
AU - Yamauchi, J.
AU - Miyazaki, T.
AU - Kobayashi, T.
AU - Nozawa, S.
PY - 1994
Y1 - 1994
N2 - We conducted a cohort analytic study to determine whether an unexplained increase in maternal serum alpha-fetoprotein (MSAFP) or human chorionic gonadotropin (MShCG) is effective in screening for adverse perinatal outcomes. MSAFP and MShCG levels were measured in 1,097 consecutive pregnant women in whom gestation was dated by ultrasonography and who later delivered a single infant. Patients with high MSAFP or MShCG had a much higher risk of low birth weight, intrauterine growth retardation and fetal death. But a screening test with MShCG for predicting preterm birth, low birth weight and intrauterine growth retardation had an approximately twice higher sensitivity than that with MSAFP. A combination of MSAFP and MShCG had little effect on the sensitivity. We concluded that a screening test with MShCG alone might be useful in predicting adverse perinatal outcomes.
AB - We conducted a cohort analytic study to determine whether an unexplained increase in maternal serum alpha-fetoprotein (MSAFP) or human chorionic gonadotropin (MShCG) is effective in screening for adverse perinatal outcomes. MSAFP and MShCG levels were measured in 1,097 consecutive pregnant women in whom gestation was dated by ultrasonography and who later delivered a single infant. Patients with high MSAFP or MShCG had a much higher risk of low birth weight, intrauterine growth retardation and fetal death. But a screening test with MShCG for predicting preterm birth, low birth weight and intrauterine growth retardation had an approximately twice higher sensitivity than that with MSAFP. A combination of MSAFP and MShCG had little effect on the sensitivity. We concluded that a screening test with MShCG alone might be useful in predicting adverse perinatal outcomes.
KW - adverse perinatal outcome
KW - alpha-fetoprotein
KW - human chorionic gonadotropin
KW - maternal serum
UR - http://www.scopus.com/inward/record.url?scp=0027943178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027943178&partnerID=8YFLogxK
M3 - Article
C2 - 7531210
AN - SCOPUS:0027943178
VL - 46
SP - 1229
EP - 1233
JO - Nippon Sanka Fujinka Gakkai zasshi
JF - Nippon Sanka Fujinka Gakkai zasshi
SN - 0300-9165
IS - 11
ER -