Abstract
The applicability of liquid chromatography/iontrap tandem mass spectrometry (iontrap LC/MS/MS) to screening for 44 veterinary drugs in livestock foods and fish was examined. Mass spectral acquisition was performed in both the positive and negative modes. In LC separation, a CadenzaCD-C18 column was used with 0.1% formic acid-acetonitrile as the mobile phase. The drugs were extracted from livestock foods and fish with acetonitrile/hexane saturated acetonitrile, and cleaned up by a OasisHLB cartridge. The precursor ion and product ions obtained under the EPI mode were key criteria to confirm the identity of veterinary drugs in samples. The MRM mode was obtained with a sensitive analysis. The iontrap LC/MS/MS technique is useful for screening residual veterinary drugs present at low levels in livestock foods and fish.
| Original language | English |
|---|---|
| Pages (from-to) | 1105-1113 |
| Number of pages | 9 |
| Journal | Bunseki Kagaku |
| Volume | 56 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2007 |
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Keywords
- Cartridge column
- Iontrap tandem mass spectrometry
- Livestock foods and fish
- Veterinary drugs
ASJC Scopus subject areas
- Analytical Chemistry
Cite this
Screening method for veterinary drugs in livestock foods and fish by liquid chromatography/tandem mass spectrometry. / Kai, Shigemi; Akaboshi, Takeshi; Fujimaki, Teruhisa; Itoh, Shin Ichi; Kanazawa, Hideko.
In: Bunseki Kagaku, Vol. 56, No. 12, 2007, p. 1105-1113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Screening method for veterinary drugs in livestock foods and fish by liquid chromatography/tandem mass spectrometry
AU - Kai, Shigemi
AU - Akaboshi, Takeshi
AU - Fujimaki, Teruhisa
AU - Itoh, Shin Ichi
AU - Kanazawa, Hideko
PY - 2007
Y1 - 2007
N2 - The applicability of liquid chromatography/iontrap tandem mass spectrometry (iontrap LC/MS/MS) to screening for 44 veterinary drugs in livestock foods and fish was examined. Mass spectral acquisition was performed in both the positive and negative modes. In LC separation, a CadenzaCD-C18 column was used with 0.1% formic acid-acetonitrile as the mobile phase. The drugs were extracted from livestock foods and fish with acetonitrile/hexane saturated acetonitrile, and cleaned up by a OasisHLB cartridge. The precursor ion and product ions obtained under the EPI mode were key criteria to confirm the identity of veterinary drugs in samples. The MRM mode was obtained with a sensitive analysis. The iontrap LC/MS/MS technique is useful for screening residual veterinary drugs present at low levels in livestock foods and fish.
AB - The applicability of liquid chromatography/iontrap tandem mass spectrometry (iontrap LC/MS/MS) to screening for 44 veterinary drugs in livestock foods and fish was examined. Mass spectral acquisition was performed in both the positive and negative modes. In LC separation, a CadenzaCD-C18 column was used with 0.1% formic acid-acetonitrile as the mobile phase. The drugs were extracted from livestock foods and fish with acetonitrile/hexane saturated acetonitrile, and cleaned up by a OasisHLB cartridge. The precursor ion and product ions obtained under the EPI mode were key criteria to confirm the identity of veterinary drugs in samples. The MRM mode was obtained with a sensitive analysis. The iontrap LC/MS/MS technique is useful for screening residual veterinary drugs present at low levels in livestock foods and fish.
KW - Cartridge column
KW - Iontrap tandem mass spectrometry
KW - Livestock foods and fish
KW - Veterinary drugs
UR - http://www.scopus.com/inward/record.url?scp=39049087612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049087612&partnerID=8YFLogxK
U2 - 10.2116/bunsekikagaku.56.1105
DO - 10.2116/bunsekikagaku.56.1105
M3 - Article
AN - SCOPUS:39049087612
VL - 56
SP - 1105
EP - 1113
JO - Bunseki Kagaku
JF - Bunseki Kagaku
SN - 0525-1931
IS - 12
ER -