Screening of autoantibodies associated with necrotizing myopathy among undiagnosed chronic myopathy

Satoshi Kuru, Shigeaki Suzuki, Katsuhisa Ogata, Michio Kobayashi, Chiho Ishida, Chigusa Watanabe, Tsuyoshi Matsumura

Research output: Contribution to journalArticle


We screened anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies among 42 patients who had undiagnosed chronic myopathy from six national hospitals. Anti-SRP and anti-HMGCR antibodies were determined by RNA immuneprecipitation and enzyme-linked immune-sorbent assay (ELISA), respectively. We identified two patients with anti-SRP antibodies (4.7%) and, two with anti-HMGCR antibodies (4.7%). Both of anti-SRP-positive patients showed dysphagia with a high level of creatine kinase. Anti-HMGCR antibodies were associated with mild muscle weakness with a relatively late disease onset. Our study suggests the importance of autoantibody testing among undiagnosed chronic myopathy.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
JournalClinical Neurology
Issue number10
Publication statusPublished - 2017 Jan 1



  • Anti-HMGCR antibody
  • Anti-SRP antibody
  • Chronic myopathy
  • Immune-mediated necrotizing myopathy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this