Screening of autoantibodies associated with necrotizing myopathy among undiagnosed chronic myopathy

Satoshi Kuru, Shigeaki Suzuki, Katsuhisa Ogata, Michio Kobayashi, Chiho Ishida, Chigusa Watanabe, Tsuyoshi Matsumura

Research output: Contribution to journalArticle

Abstract

We screened anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies among 42 patients who had undiagnosed chronic myopathy from six national hospitals. Anti-SRP and anti-HMGCR antibodies were determined by RNA immuneprecipitation and enzyme-linked immune-sorbent assay (ELISA), respectively. We identified two patients with anti-SRP antibodies (4.7%) and, two with anti-HMGCR antibodies (4.7%). Both of anti-SRP-positive patients showed dysphagia with a high level of creatine kinase. Anti-HMGCR antibodies were associated with mild muscle weakness with a relatively late disease onset. Our study suggests the importance of autoantibody testing among undiagnosed chronic myopathy.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
JournalClinical Neurology
Volume57
Issue number10
DOIs
Publication statusPublished - 2017 Jan 1

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Signal Recognition Particle
Muscular Diseases
Autoantibodies
Oxidoreductases
Antibodies
Muscle Weakness
Creatine Kinase
Deglutition Disorders
RNA
3-hydroxy-3-methylglutaryl-coenzyme A
Enzymes

Keywords

  • Anti-HMGCR antibody
  • Anti-SRP antibody
  • Chronic myopathy
  • Immune-mediated necrotizing myopathy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Screening of autoantibodies associated with necrotizing myopathy among undiagnosed chronic myopathy. / Kuru, Satoshi; Suzuki, Shigeaki; Ogata, Katsuhisa; Kobayashi, Michio; Ishida, Chiho; Watanabe, Chigusa; Matsumura, Tsuyoshi.

In: Clinical Neurology, Vol. 57, No. 10, 01.01.2017, p. 562-566.

Research output: Contribution to journalArticle

Kuru, Satoshi ; Suzuki, Shigeaki ; Ogata, Katsuhisa ; Kobayashi, Michio ; Ishida, Chiho ; Watanabe, Chigusa ; Matsumura, Tsuyoshi. / Screening of autoantibodies associated with necrotizing myopathy among undiagnosed chronic myopathy. In: Clinical Neurology. 2017 ; Vol. 57, No. 10. pp. 562-566.
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