Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis

F. Kiuchi, M. Hayashi, N. Nakamura, M. Mikage, Y. Tsuda, K. Kondo, T. Namba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hot water extracts of 160 crude drugs used in Nepal were tested for their in vitro nematocidal activity on the second-stage larva of the dog roundworm, Toxocara cains, which is a common pathogenic parasite in larva migrans. Twenty-two of them showed a potent nematocidal activity (RM = 0, after 24 h incubation), and the activities of ''Bojho'' (rhizome of Acorus calamus L.) and ''Pan ko Jara'' (rhizome of Alpinia galanga SWARTZ) were particularly strong (RM = 0, after 6 h incubation). The active principle of Pan ko Jara was identified as [S]-1'-acetoxychavicol acetate.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalJapanese Journal of Pharmacognosy
Volume43
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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    Kiuchi, F., Hayashi, M., Nakamura, N., Mikage, M., Tsuda, Y., Kondo, K., & Namba, T. (1989). Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis. Japanese Journal of Pharmacognosy, 43(4), 294-299.