Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis

Fumiyuki Kiuchi, M. Hayashi, N. Nakamura, M. Mikage, Y. Tsuda, K. Kondo, T. Namba

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Abstract

Hot water extracts of 160 crude drugs used in Nepal were tested for their in vitro nematocidal activity on the second-stage larva of the dog roundworm, Toxocara cains, which is a common pathogenic parasite in larva migrans. Twenty-two of them showed a potent nematocidal activity (RM = 0, after 24 h incubation), and the activities of ''Bojho'' (rhizome of Acorus calamus L.) and ''Pan ko Jara'' (rhizome of Alpinia galanga SWARTZ) were particularly strong (RM = 0, after 6 h incubation). The active principle of Pan ko Jara was identified as [S]-1'-acetoxychavicol acetate.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalJapanese Journal of Pharmacognosy
Volume43
Issue number4
Publication statusPublished - 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Kiuchi, F., Hayashi, M., Nakamura, N., Mikage, M., Tsuda, Y., Kondo, K., & Namba, T. (1989). Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis. Japanese Journal of Pharmacognosy, 43(4), 294-299.