Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis

Fumiyuki Kiuchi, M. Hayashi, N. Nakamura, M. Mikage, Y. Tsuda, K. Kondo, T. Namba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hot water extracts of 160 crude drugs used in Nepal were tested for their in vitro nematocidal activity on the second-stage larva of the dog roundworm, Toxocara cains, which is a common pathogenic parasite in larva migrans. Twenty-two of them showed a potent nematocidal activity (RM = 0, after 24 h incubation), and the activities of ''Bojho'' (rhizome of Acorus calamus L.) and ''Pan ko Jara'' (rhizome of Alpinia galanga SWARTZ) were particularly strong (RM = 0, after 6 h incubation). The active principle of Pan ko Jara was identified as [S]-1'-acetoxychavicol acetate.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalJapanese Journal of Pharmacognosy
Volume43
Issue number4
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Acorus
Toxocara canis
Nepal
Preclinical Drug Evaluations
Rhizome
Larva
Screening
Alpinia
Larva Migrans
Toxocara
Water
Complex Mixtures
Pharmaceutical Preparations
Parasites
Dogs
1'-acetoxychavicol acetate

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Kiuchi, F., Hayashi, M., Nakamura, N., Mikage, M., Tsuda, Y., Kondo, K., & Namba, T. (1989). Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis. Japanese Journal of Pharmacognosy, 43(4), 294-299.

Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis. / Kiuchi, Fumiyuki; Hayashi, M.; Nakamura, N.; Mikage, M.; Tsuda, Y.; Kondo, K.; Namba, T.

In: Japanese Journal of Pharmacognosy, Vol. 43, No. 4, 1989, p. 294-299.

Research output: Contribution to journalArticle

Kiuchi, F, Hayashi, M, Nakamura, N, Mikage, M, Tsuda, Y, Kondo, K & Namba, T 1989, 'Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis', Japanese Journal of Pharmacognosy, vol. 43, no. 4, pp. 294-299.
Kiuchi, Fumiyuki ; Hayashi, M. ; Nakamura, N. ; Mikage, M. ; Tsuda, Y. ; Kondo, K. ; Namba, T. / Screening of crude drugs used in Nepal for nematocidal activity on the larva of toxocara canis. In: Japanese Journal of Pharmacognosy. 1989 ; Vol. 43, No. 4. pp. 294-299.
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