Screening of natural medicines used in Vietnam for trypanocidal activity against epimastigotes of Trypanosoma cruzi

Fumiyuki Kiuchi, Kenji Matsuo, Yoshiaki Itano, Michiho Ito, Gisho Honda, Tran Kim Qui, Junko Nakajima-Shimada, Takashi Aoki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Acetone, MeOH, and water extracts of 90 natural medicines used in Vietnam were tested for their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the causative agent of Chagas' disease. Strong trypanocidal activity was found in the acetone extracts of 7 natural medicines, i.e. chân bâu (Combretum quadrangulare), khô sâm bāc (Sophora flavescens), by lá môt hoa (Paris polyphylla), cao luong khuong (Alpinia galanga), hāc huong (Pogostemon cablin), màn kinh tu(Vitex trifolia), thach hôc (Dendrobium nobile). l'-Acetoxychavicol acetate (1) and related phenylpropanoids were identified as the trypanocidal constituents of cao luong khuong.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalNatural Medicines
Volume56
Issue number2
Publication statusPublished - 2002 Jan 1
Externally publishedYes

Keywords

  • Alpinia galanga
  • Epimastigote
  • Natural medicine
  • Trypanocidal activity
  • Trypanosoma cruzi
  • Vietnam

ASJC Scopus subject areas

  • Molecular Medicine

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  • Cite this

    Kiuchi, F., Matsuo, K., Itano, Y., Ito, M., Honda, G., Qui, T. K., Nakajima-Shimada, J., & Aoki, T. (2002). Screening of natural medicines used in Vietnam for trypanocidal activity against epimastigotes of Trypanosoma cruzi. Natural Medicines, 56(2), 64-68.