Sealing of a drain hole using 2-octylcyanoacrylate monomer after lymphadenectomy for gynecologic cancer

In this study, the authors investigated whether lymphocele infection can be prevented using 2-octyl cyanoacrylate monomer, a skin closure material that provides a microbial barrier. The subjects were 34 patients treated with 2-octyl cyanoacrylate monomer to close the drain hole (n=17) or with natural drain closure only (n=17). In the control group, eight cases (47.1%) had leakage of lymph fluid that required regular changes of dressing after removal of the catheter, seven (41.1%) had lymphocele, and three (17.6%) developed lymphocele with infection. In contrast, in the 2-octyl cyanoacrylate monomer group, no cases had long-term leakage of lymph fluid and none required dressing changes, although three had leakage after the first application and required a second application of 2-octyl cyanoacrylate monomer for closure. Six cases (35.3%) had lymphocele and there were no cases with infection in the 2-octyl cyanoacrylate monomer group. 2-octyl cyanoacrylate monomer may contribute to reduction of the incidence of lymphocele infection and reduce the clinical burden caused by dressing changes.