Search for a susceptibility locus to tardive dyskinesia

Toshiya Inada, Izumi Dobashi, Tetsuyoshi Sugita, Ataru Inagaki, Yoshie Kitao, Genichi Matsuda, Shingo Kato, Toshiya Takano, Gohei Yagi, Masahiro Asai

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalHuman Psychopharmacology
Volume12
Issue number1
DOIs
Publication statusPublished - 1997 Jan 1

Keywords

  • DRD2
  • DRD3
  • dopamine transporter
  • gene
  • polymorphism
  • tardive dyskinesia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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