Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer

Shigenari Nukaga, Katsuhiko Naoki, Hiroyuki Yasuda, Ichiro Kawada, Kentaro Ohara, Kenzo Soejima, Tomoko Betsuyaku

Research output: Contribution to journalArticle

Abstract

Stereotactic radiosurgery (SRS) using the Gamma Knife (GK) is now being increasingly utilized for the treatment of brain metastases. However, there are a few reported cases of SRS-induced brain neoplasms. We herein report the case of a Japanese woman with metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor (EGFR)-mutations who was treated four times with a GK for brain metastases. She developed glioblastoma 5.7 years after the initial GK surgery. Radiation-induced secondary neoplasms generally appear after a latency period of several years. Advances in cancer therapy have improved the survival of patients with NSCLC, providing enough time for secondary neoplasms to appear after SRS.

Original languageEnglish
Pages (from-to)2383-2387
Number of pages5
JournalInternal Medicine
Volume57
Issue number16
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Radiosurgery
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Radiation-Induced Neoplasms
Neoplasm Metastasis
Brain
Glioblastoma
Epidermal Growth Factor
Neoplasms
Mutation
Survival
Therapeutics

Keywords

  • Brain metastases
  • Non-small cell lung cancer
  • Radiosurgery induced brain neoplasm
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer. / Nukaga, Shigenari; Naoki, Katsuhiko; Yasuda, Hiroyuki; Kawada, Ichiro; Ohara, Kentaro; Soejima, Kenzo; Betsuyaku, Tomoko.

In: Internal Medicine, Vol. 57, No. 16, 01.01.2018, p. 2383-2387.

Research output: Contribution to journalArticle

Nukaga, Shigenari ; Naoki, Katsuhiko ; Yasuda, Hiroyuki ; Kawada, Ichiro ; Ohara, Kentaro ; Soejima, Kenzo ; Betsuyaku, Tomoko. / Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer. In: Internal Medicine. 2018 ; Vol. 57, No. 16. pp. 2383-2387.
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