Secondary Metabolites with New Medicinal Functions from Marine Organisms

Osamu Ohno, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have focused on the identification of natural key compounds that possess biologically and medicinally intriguing functions. Some of bioactive naturally occurring compounds isolated from marine organisms were found to possess unique biological activities. Halichlorine from the marine sponge Halichondria okadai was shown to inhibit the activity of nuclear factor-κB in endothelial cells and block L-type Ca 2+ channels. Thus, it may have therapeutic potentials for diseases such as atherosclerosis and hypertension.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalAdvances in Food and Nutrition Research
Volume65
DOIs
Publication statusPublished - 2012

Fingerprint

Aquatic Organisms
Porifera
atherosclerosis
secondary metabolites
hypertension
endothelial cells
bioactive properties
Atherosclerosis
Endothelial Cells
Hypertension
therapeutics
organisms
Therapeutics
halichlorine

Keywords

  • Atherosclerosis
  • Halichlorine
  • Marine organisms
  • Secondary metabolites

ASJC Scopus subject areas

  • Food Science

Cite this

Secondary Metabolites with New Medicinal Functions from Marine Organisms. / Ohno, Osamu; Suenaga, Kiyotake; Uemura, Daisuke.

In: Advances in Food and Nutrition Research, Vol. 65, 2012, p. 185-193.

Research output: Contribution to journalArticle

@article{502e8943ba86476e90244ea400cbaf7c,
title = "Secondary Metabolites with New Medicinal Functions from Marine Organisms",
abstract = "We have focused on the identification of natural key compounds that possess biologically and medicinally intriguing functions. Some of bioactive naturally occurring compounds isolated from marine organisms were found to possess unique biological activities. Halichlorine from the marine sponge Halichondria okadai was shown to inhibit the activity of nuclear factor-κB in endothelial cells and block L-type Ca 2+ channels. Thus, it may have therapeutic potentials for diseases such as atherosclerosis and hypertension.",
keywords = "Atherosclerosis, Halichlorine, Marine organisms, Secondary metabolites",
author = "Osamu Ohno and Kiyotake Suenaga and Daisuke Uemura",
year = "2012",
doi = "10.1016/B978-0-12-416003-3.00011-1",
language = "English",
volume = "65",
pages = "185--193",
journal = "Advances in Food and Nutrition Research",
issn = "1043-4526",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Secondary Metabolites with New Medicinal Functions from Marine Organisms

AU - Ohno, Osamu

AU - Suenaga, Kiyotake

AU - Uemura, Daisuke

PY - 2012

Y1 - 2012

N2 - We have focused on the identification of natural key compounds that possess biologically and medicinally intriguing functions. Some of bioactive naturally occurring compounds isolated from marine organisms were found to possess unique biological activities. Halichlorine from the marine sponge Halichondria okadai was shown to inhibit the activity of nuclear factor-κB in endothelial cells and block L-type Ca 2+ channels. Thus, it may have therapeutic potentials for diseases such as atherosclerosis and hypertension.

AB - We have focused on the identification of natural key compounds that possess biologically and medicinally intriguing functions. Some of bioactive naturally occurring compounds isolated from marine organisms were found to possess unique biological activities. Halichlorine from the marine sponge Halichondria okadai was shown to inhibit the activity of nuclear factor-κB in endothelial cells and block L-type Ca 2+ channels. Thus, it may have therapeutic potentials for diseases such as atherosclerosis and hypertension.

KW - Atherosclerosis

KW - Halichlorine

KW - Marine organisms

KW - Secondary metabolites

UR - http://www.scopus.com/inward/record.url?scp=84857221560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857221560&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-416003-3.00011-1

DO - 10.1016/B978-0-12-416003-3.00011-1

M3 - Article

C2 - 22361187

AN - SCOPUS:84857221560

VL - 65

SP - 185

EP - 193

JO - Advances in Food and Nutrition Research

JF - Advances in Food and Nutrition Research

SN - 1043-4526

ER -