In late years, many base isolated structures are planned as the seismic design, because they suppress vibration response significantly against large earthquake. To achieve greater safety, semi-active or active vibration control system is installed in the structures as earthquake countermeasures. Semi-active and active vibration control systems are more effective than passive vibration control system to large earthquake in terms of vibration reduction. However semi-active and active vibration control system cannot operate as required when external power supply is cut off. To solve the problem of energy consumption, we propose a self-powered active seismic isolation floor which achieve active control system using regenerated vibration energy. This device doesn't require external energy to produce control force. The purpose of this study is to propose the seismic isolation device having charging function and to optimize the control system and passive elements such as spring coefficients and damping coefficients using genetic algorithm. As a result, optimized model shows better performance in terms of vibration reduction and electric power regeneration than the previous model. At the end of this paper, the experimental specimen of the proposed isolation device is shown.