Selective activation of calcium permeability by aspartate in Purkinje cells

Michisuke Yuzaki, Douglas Forrest, Tom Curran, John A. Connor

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Glutamate and aspartate are endogenous excitatory amino acid neurotransmitters widely distributed in the mammalian central nervous system. Aspartate was shown to induce a large membrane current sensitive to N- methyI-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)). This response was accompanied by high permeability to calcium. In contrast, no current was induced by aspartate in hippocampal neurons and cerebellar granule cells from NR1-/- mice. Several other glutamate receptor agonists failed to evoke this response. Thus, in Purkinje cells, aspartate activates a distinct response capable of contributing to synaptic plasticity through calcium permeability.

Original languageEnglish
Pages (from-to)1112-1114
Number of pages3
JournalScience
Volume273
Issue number5278
DOIs
Publication statusPublished - 1996 Aug 23
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Selective activation of calcium permeability by aspartate in Purkinje cells'. Together they form a unique fingerprint.

Cite this