Selective activation of calcium permeability by aspartate in Purkinje cells

Michisuke Yuzaki, Douglas Forrest, Tom Curran, John A. Connor

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Glutamate and aspartate are endogenous excitatory amino acid neurotransmitters widely distributed in the mammalian central nervous system. Aspartate was shown to induce a large membrane current sensitive to N- methyI-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)). This response was accompanied by high permeability to calcium. In contrast, no current was induced by aspartate in hippocampal neurons and cerebellar granule cells from NR1-/- mice. Several other glutamate receptor agonists failed to evoke this response. Thus, in Purkinje cells, aspartate activates a distinct response capable of contributing to synaptic plasticity through calcium permeability.

Original languageEnglish
Pages (from-to)1112-1114
Number of pages3
JournalScience
Volume273
Issue number5278
Publication statusPublished - 1996 Aug 23
Externally publishedYes

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Purkinje Cells
D-Aspartic Acid
Aspartic Acid
Permeability
Calcium
Excitatory Amino Acid Agonists
Excitatory Amino Acids
Neuronal Plasticity
Glutamate Receptors
Neurotransmitter Agents
Glutamic Acid
Central Nervous System
Neurons
Membranes
aspartic acid receptor

ASJC Scopus subject areas

  • General

Cite this

Yuzaki, M., Forrest, D., Curran, T., & Connor, J. A. (1996). Selective activation of calcium permeability by aspartate in Purkinje cells. Science, 273(5278), 1112-1114.

Selective activation of calcium permeability by aspartate in Purkinje cells. / Yuzaki, Michisuke; Forrest, Douglas; Curran, Tom; Connor, John A.

In: Science, Vol. 273, No. 5278, 23.08.1996, p. 1112-1114.

Research output: Contribution to journalArticle

Yuzaki, M, Forrest, D, Curran, T & Connor, JA 1996, 'Selective activation of calcium permeability by aspartate in Purkinje cells', Science, vol. 273, no. 5278, pp. 1112-1114.
Yuzaki M, Forrest D, Curran T, Connor JA. Selective activation of calcium permeability by aspartate in Purkinje cells. Science. 1996 Aug 23;273(5278):1112-1114.
Yuzaki, Michisuke ; Forrest, Douglas ; Curran, Tom ; Connor, John A. / Selective activation of calcium permeability by aspartate in Purkinje cells. In: Science. 1996 ; Vol. 273, No. 5278. pp. 1112-1114.
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