Selective ligation of portal vein and hepatic artery for ruptured hepatocellular carcinoma in a 13-year-old boy

Hideaki Tanaka, Toshiro Honna, Mitsuru Muto, Akihiro Fujino, Mureo Kasahara, Yoshihiro Kitano, Tatsuo Kuroda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) in children is rare, and the prognosis has been poor because of its advanced stage at diagnosis and unresponsiveness to chemotherapy. We report a 13-year-old boy with ruptured HCC in the left trisegment. When hemostasis of the ruptured surface was achieved in the emergency operation, the left branch of the portal vein and the left hepatic artery were ligated at the same time. The volume of the future liver remnant (FLR), that is, his right posterior sector, increased from 56% on admission to 70% of his standard liver volume on day 2. Blood level of serum protein induced by vitamin K absence or antagonist II started to decrease immediately. Left trisegmentectomy was successfully performed 10 days later, followed by chemotherapy. He has been well with a 2-year survival without recurrence. When the FLR is considered relatively small for a major hepatic resection, the selective ligation of the portal vein and the hepatic artery, which feed HCC, seems to be beneficial. This is because it may induce enlargement of the FLR, increasing the safety of the hepatectomy as preoperative portal vein embolization does before a major hepatectomy in adult patients with HCC, and the latter suppresses the tumor while waiting for the planned hepatectomy.

Original languageEnglish
Pages (from-to)973-977
Number of pages5
JournalJournal of Pediatric Surgery
Volume46
Issue number5
DOIs
Publication statusPublished - 2011 May
Externally publishedYes

Fingerprint

Hepatic Artery
Portal Vein
Ligation
Hepatocellular Carcinoma
Hepatectomy
Liver
Drug Therapy
Hemostasis
Blood Proteins
Emergencies
Safety
Recurrence
Survival
Serum
Neoplasms

Keywords

  • Children
  • Hepatic artery ligation
  • Portal vein ligation
  • Ruptured hepatocellular carcinoma

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Selective ligation of portal vein and hepatic artery for ruptured hepatocellular carcinoma in a 13-year-old boy. / Tanaka, Hideaki; Honna, Toshiro; Muto, Mitsuru; Fujino, Akihiro; Kasahara, Mureo; Kitano, Yoshihiro; Kuroda, Tatsuo.

In: Journal of Pediatric Surgery, Vol. 46, No. 5, 05.2011, p. 973-977.

Research output: Contribution to journalArticle

Tanaka, Hideaki ; Honna, Toshiro ; Muto, Mitsuru ; Fujino, Akihiro ; Kasahara, Mureo ; Kitano, Yoshihiro ; Kuroda, Tatsuo. / Selective ligation of portal vein and hepatic artery for ruptured hepatocellular carcinoma in a 13-year-old boy. In: Journal of Pediatric Surgery. 2011 ; Vol. 46, No. 5. pp. 973-977.
@article{b95d8f37dc6c42aa950d4dbfbc9777fc,
title = "Selective ligation of portal vein and hepatic artery for ruptured hepatocellular carcinoma in a 13-year-old boy",
abstract = "Hepatocellular carcinoma (HCC) in children is rare, and the prognosis has been poor because of its advanced stage at diagnosis and unresponsiveness to chemotherapy. We report a 13-year-old boy with ruptured HCC in the left trisegment. When hemostasis of the ruptured surface was achieved in the emergency operation, the left branch of the portal vein and the left hepatic artery were ligated at the same time. The volume of the future liver remnant (FLR), that is, his right posterior sector, increased from 56{\%} on admission to 70{\%} of his standard liver volume on day 2. Blood level of serum protein induced by vitamin K absence or antagonist II started to decrease immediately. Left trisegmentectomy was successfully performed 10 days later, followed by chemotherapy. He has been well with a 2-year survival without recurrence. When the FLR is considered relatively small for a major hepatic resection, the selective ligation of the portal vein and the hepatic artery, which feed HCC, seems to be beneficial. This is because it may induce enlargement of the FLR, increasing the safety of the hepatectomy as preoperative portal vein embolization does before a major hepatectomy in adult patients with HCC, and the latter suppresses the tumor while waiting for the planned hepatectomy.",
keywords = "Children, Hepatic artery ligation, Portal vein ligation, Ruptured hepatocellular carcinoma",
author = "Hideaki Tanaka and Toshiro Honna and Mitsuru Muto and Akihiro Fujino and Mureo Kasahara and Yoshihiro Kitano and Tatsuo Kuroda",
year = "2011",
month = "5",
doi = "10.1016/j.jpedsurg.2011.01.016",
language = "English",
volume = "46",
pages = "973--977",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Selective ligation of portal vein and hepatic artery for ruptured hepatocellular carcinoma in a 13-year-old boy

AU - Tanaka, Hideaki

AU - Honna, Toshiro

AU - Muto, Mitsuru

AU - Fujino, Akihiro

AU - Kasahara, Mureo

AU - Kitano, Yoshihiro

AU - Kuroda, Tatsuo

PY - 2011/5

Y1 - 2011/5

N2 - Hepatocellular carcinoma (HCC) in children is rare, and the prognosis has been poor because of its advanced stage at diagnosis and unresponsiveness to chemotherapy. We report a 13-year-old boy with ruptured HCC in the left trisegment. When hemostasis of the ruptured surface was achieved in the emergency operation, the left branch of the portal vein and the left hepatic artery were ligated at the same time. The volume of the future liver remnant (FLR), that is, his right posterior sector, increased from 56% on admission to 70% of his standard liver volume on day 2. Blood level of serum protein induced by vitamin K absence or antagonist II started to decrease immediately. Left trisegmentectomy was successfully performed 10 days later, followed by chemotherapy. He has been well with a 2-year survival without recurrence. When the FLR is considered relatively small for a major hepatic resection, the selective ligation of the portal vein and the hepatic artery, which feed HCC, seems to be beneficial. This is because it may induce enlargement of the FLR, increasing the safety of the hepatectomy as preoperative portal vein embolization does before a major hepatectomy in adult patients with HCC, and the latter suppresses the tumor while waiting for the planned hepatectomy.

AB - Hepatocellular carcinoma (HCC) in children is rare, and the prognosis has been poor because of its advanced stage at diagnosis and unresponsiveness to chemotherapy. We report a 13-year-old boy with ruptured HCC in the left trisegment. When hemostasis of the ruptured surface was achieved in the emergency operation, the left branch of the portal vein and the left hepatic artery were ligated at the same time. The volume of the future liver remnant (FLR), that is, his right posterior sector, increased from 56% on admission to 70% of his standard liver volume on day 2. Blood level of serum protein induced by vitamin K absence or antagonist II started to decrease immediately. Left trisegmentectomy was successfully performed 10 days later, followed by chemotherapy. He has been well with a 2-year survival without recurrence. When the FLR is considered relatively small for a major hepatic resection, the selective ligation of the portal vein and the hepatic artery, which feed HCC, seems to be beneficial. This is because it may induce enlargement of the FLR, increasing the safety of the hepatectomy as preoperative portal vein embolization does before a major hepatectomy in adult patients with HCC, and the latter suppresses the tumor while waiting for the planned hepatectomy.

KW - Children

KW - Hepatic artery ligation

KW - Portal vein ligation

KW - Ruptured hepatocellular carcinoma

UR - http://www.scopus.com/inward/record.url?scp=79957567752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957567752&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2011.01.016

DO - 10.1016/j.jpedsurg.2011.01.016

M3 - Article

VL - 46

SP - 973

EP - 977

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 5

ER -