Abstract
A catalyst system consisting of RuHCl(CO)(PiPr3)2, CsF, and a styrene derivative was found to be applicable to selective monoarylation of aromatic ketones via ortho C-H bond cleavage. The reaction of 2′-methoxyacetophenone with arylboronates gave C-H arylation products without cleaving the ortho C-O bond. Acetophenone was also converted to monoarylation products with high selectivity. Cyclohexanone was found to be an effective solvent for the C-H arylation using the catalyst system.
| Original language | English |
|---|---|
| Pages (from-to) | 12975-12982 |
| Number of pages | 8 |
| Journal | Journal of Organic Chemistry |
| Volume | 84 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2019 Oct 18 |
ASJC Scopus subject areas
- Organic Chemistry
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Cite this
Suzuki, I., Kondo, H., Kochi, T., & Kakiuchi, F. (2019). Selective Monoarylation of Aromatic Ketones via C-H Bond Cleavage by Trialkylphosphine Ruthenium Catalysts. Journal of Organic Chemistry, 84(20), 12975-12982. https://doi.org/10.1021/acs.joc.9b01756