Selective Monoarylation of Aromatic Ketones via C-H Bond Cleavage by Trialkylphosphine Ruthenium Catalysts

Issei Suzuki, Hikaru Kondo, Takuya Kochi, Fumitoshi Kakiuchi

Research output: Contribution to journalArticle

Abstract

A catalyst system consisting of RuHCl(CO)(PiPr3)2, CsF, and a styrene derivative was found to be applicable to selective monoarylation of aromatic ketones via ortho C-H bond cleavage. The reaction of 2′-methoxyacetophenone with arylboronates gave C-H arylation products without cleaving the ortho C-O bond. Acetophenone was also converted to monoarylation products with high selectivity. Cyclohexanone was found to be an effective solvent for the C-H arylation using the catalyst system.

Original languageEnglish
Pages (from-to)12975-12982
Number of pages8
JournalJournal of Organic Chemistry
Volume84
Issue number20
DOIs
Publication statusPublished - 2019 Oct 18

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ASJC Scopus subject areas

  • Organic Chemistry

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