Self-assembly behaviours of primitive and modern lipid membrane solutions: A coarse-grained molecular simulation study

Noriyoshi Arai, Yuki Yoshimoto, Kenji Yasuoka, Toshikazu Ebisuzaki

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Researchers have studied the origin of life and the process of evolution on early Earth for decades. However, we lack a comprehensive understanding of biogenesis, because there are many stages in the formation and growth of the first cell. We investigate the self-replication processes of coacervate protocells using computer simulations of single-chain lipid and phospholipid aqueous mixtures. Based on a morphological phase diagram, we develop a model of prebiotic self-replication driven by only environmental factors (i.e. temperature and lipid concentrations) without any external force. Moreover, we investigate high concentration structures during the process of self-replication. These structures have an advantage in fusion and repair of cell membranes. Therefore, lipid hot spots may have existed in primordial soup.

Original languageEnglish
Pages (from-to)19426-19432
Number of pages7
JournalPhysical Chemistry Chemical Physics
Volume18
Issue number28
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Self-assembly behaviours of primitive and modern lipid membrane solutions: A coarse-grained molecular simulation study'. Together they form a unique fingerprint.

Cite this