Self-assembly behaviours of primitive and modern lipid membrane solutions

A coarse-grained molecular simulation study

Noriyoshi Arai, Yuki Yoshimoto, Kenji Yasuoka, Toshikazu Ebisuzaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Researchers have studied the origin of life and the process of evolution on early Earth for decades. However, we lack a comprehensive understanding of biogenesis, because there are many stages in the formation and growth of the first cell. We investigate the self-replication processes of coacervate protocells using computer simulations of single-chain lipid and phospholipid aqueous mixtures. Based on a morphological phase diagram, we develop a model of prebiotic self-replication driven by only environmental factors (i.e. temperature and lipid concentrations) without any external force. Moreover, we investigate high concentration structures during the process of self-replication. These structures have an advantage in fusion and repair of cell membranes. Therefore, lipid hot spots may have existed in primordial soup.

Original languageEnglish
Pages (from-to)19426-19432
Number of pages7
JournalPhysical Chemistry Chemical Physics
Volume18
Issue number28
DOIs
Publication statusPublished - 2016

Fingerprint

Membrane Lipids
Self assembly
lipids
self assembly
membranes
Lipids
biological evolution
Prebiotics
simulation
Cell membranes
Phase diagrams
Phospholipids
Repair
Fusion reactions
computerized simulation
fusion
Earth (planet)
phase diagrams
Computer simulation
cells

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

Cite this

Self-assembly behaviours of primitive and modern lipid membrane solutions : A coarse-grained molecular simulation study. / Arai, Noriyoshi; Yoshimoto, Yuki; Yasuoka, Kenji; Ebisuzaki, Toshikazu.

In: Physical Chemistry Chemical Physics, Vol. 18, No. 28, 2016, p. 19426-19432.

Research output: Contribution to journalArticle

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