Self-Expanding Metallic Stents Versus Surgical Intervention as Palliative Therapy for Obstructive Colorectal Cancer: A Meta-analysis

Hidena Takahashi, Koji Okabayashi, Masashi Tsuruta, Hirotoshi Hasegawa, Masashi Yahagi, Yuukou Kitagawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Although self-expanding metallic stents (SEMS) are useful tools for relieving large bowel obstructions in patients with colorectal cancer (CRC), their efficacy in a palliative setting has not been validated. This meta-analysis aimed to evaluate the feasibility of SEMS as a palliation for unresectable CRC patients with bowel obstructions and to determine their contribution to the prognosis of CRC, compared with surgical intervention.Methods: We conducted a literature search of the PubMed and Cochrane Library databases. We selected all controlled trials that compared SEMS with surgical interventions as palliative treatments in unresectable obstructive CRC patients. The primary outcome was early complications, and the secondary outcomes were mortality, other morbidities, and long-term survival rates.Results: Ten studies met our inclusion criteria. SEMS significantly reduced the risk of early complications (odds ratio [OR] 0.34; 95 % confidence interval [CI] 0.20–0.58 %; P < 0.01), mortality (OR 0.31; 95 % CI 0.15 %–0.64 %; P < 0.01), and stoma creation (OR 0.19; 95 % CI 0.12–0.28 %; P < 0.01). Although SEMS placement was significantly associated with a higher risk of perforation of the large bowel (OR 5.25 95 % CI 2.00–13.78 %; P < 0.01) and late complications (OR 1.94; 95 % CI 0.90–4.19 %; P = 0.03), it also contributed significantly to better long-term survival (hazard ratio 0.46; 95 % CI 0.31–0.68 %; P < 0.01). Conclusions: Compared with surgical intervention, SEMS could provide feasible palliation for patients with bowel obstructions and unresectable CRC, because of their acceptable morbidity rates and better patient prognoses.

Original languageEnglish
JournalPresentations from the 9th Annual Electric Utilities Environmental Conference
DOIs
Publication statusAccepted/In press - 2015 Apr 18

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Palliative Care
Stents
Meta-Analysis
Colorectal Neoplasms
Confidence Intervals
Odds Ratio
Morbidity
Mortality
PubMed
Libraries
Survival Rate
Databases
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

@article{504ba287cff8412e9c7f375d3fca7620,
title = "Self-Expanding Metallic Stents Versus Surgical Intervention as Palliative Therapy for Obstructive Colorectal Cancer: A Meta-analysis",
abstract = "Background: Although self-expanding metallic stents (SEMS) are useful tools for relieving large bowel obstructions in patients with colorectal cancer (CRC), their efficacy in a palliative setting has not been validated. This meta-analysis aimed to evaluate the feasibility of SEMS as a palliation for unresectable CRC patients with bowel obstructions and to determine their contribution to the prognosis of CRC, compared with surgical intervention.Methods: We conducted a literature search of the PubMed and Cochrane Library databases. We selected all controlled trials that compared SEMS with surgical interventions as palliative treatments in unresectable obstructive CRC patients. The primary outcome was early complications, and the secondary outcomes were mortality, other morbidities, and long-term survival rates.Results: Ten studies met our inclusion criteria. SEMS significantly reduced the risk of early complications (odds ratio [OR] 0.34; 95 {\%} confidence interval [CI] 0.20–0.58 {\%}; P < 0.01), mortality (OR 0.31; 95 {\%} CI 0.15 {\%}–0.64 {\%}; P < 0.01), and stoma creation (OR 0.19; 95 {\%} CI 0.12–0.28 {\%}; P < 0.01). Although SEMS placement was significantly associated with a higher risk of perforation of the large bowel (OR 5.25 95 {\%} CI 2.00–13.78 {\%}; P < 0.01) and late complications (OR 1.94; 95 {\%} CI 0.90–4.19 {\%}; P = 0.03), it also contributed significantly to better long-term survival (hazard ratio 0.46; 95 {\%} CI 0.31–0.68 {\%}; P < 0.01). Conclusions: Compared with surgical intervention, SEMS could provide feasible palliation for patients with bowel obstructions and unresectable CRC, because of their acceptable morbidity rates and better patient prognoses.",
author = "Hidena Takahashi and Koji Okabayashi and Masashi Tsuruta and Hirotoshi Hasegawa and Masashi Yahagi and Yuukou Kitagawa",
year = "2015",
month = "4",
day = "18",
doi = "10.1007/s00268-015-3068-7",
language = "English",
journal = "World Journal of Surgery",
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T1 - Self-Expanding Metallic Stents Versus Surgical Intervention as Palliative Therapy for Obstructive Colorectal Cancer

T2 - A Meta-analysis

AU - Takahashi, Hidena

AU - Okabayashi, Koji

AU - Tsuruta, Masashi

AU - Hasegawa, Hirotoshi

AU - Yahagi, Masashi

AU - Kitagawa, Yuukou

PY - 2015/4/18

Y1 - 2015/4/18

N2 - Background: Although self-expanding metallic stents (SEMS) are useful tools for relieving large bowel obstructions in patients with colorectal cancer (CRC), their efficacy in a palliative setting has not been validated. This meta-analysis aimed to evaluate the feasibility of SEMS as a palliation for unresectable CRC patients with bowel obstructions and to determine their contribution to the prognosis of CRC, compared with surgical intervention.Methods: We conducted a literature search of the PubMed and Cochrane Library databases. We selected all controlled trials that compared SEMS with surgical interventions as palliative treatments in unresectable obstructive CRC patients. The primary outcome was early complications, and the secondary outcomes were mortality, other morbidities, and long-term survival rates.Results: Ten studies met our inclusion criteria. SEMS significantly reduced the risk of early complications (odds ratio [OR] 0.34; 95 % confidence interval [CI] 0.20–0.58 %; P < 0.01), mortality (OR 0.31; 95 % CI 0.15 %–0.64 %; P < 0.01), and stoma creation (OR 0.19; 95 % CI 0.12–0.28 %; P < 0.01). Although SEMS placement was significantly associated with a higher risk of perforation of the large bowel (OR 5.25 95 % CI 2.00–13.78 %; P < 0.01) and late complications (OR 1.94; 95 % CI 0.90–4.19 %; P = 0.03), it also contributed significantly to better long-term survival (hazard ratio 0.46; 95 % CI 0.31–0.68 %; P < 0.01). Conclusions: Compared with surgical intervention, SEMS could provide feasible palliation for patients with bowel obstructions and unresectable CRC, because of their acceptable morbidity rates and better patient prognoses.

AB - Background: Although self-expanding metallic stents (SEMS) are useful tools for relieving large bowel obstructions in patients with colorectal cancer (CRC), their efficacy in a palliative setting has not been validated. This meta-analysis aimed to evaluate the feasibility of SEMS as a palliation for unresectable CRC patients with bowel obstructions and to determine their contribution to the prognosis of CRC, compared with surgical intervention.Methods: We conducted a literature search of the PubMed and Cochrane Library databases. We selected all controlled trials that compared SEMS with surgical interventions as palliative treatments in unresectable obstructive CRC patients. The primary outcome was early complications, and the secondary outcomes were mortality, other morbidities, and long-term survival rates.Results: Ten studies met our inclusion criteria. SEMS significantly reduced the risk of early complications (odds ratio [OR] 0.34; 95 % confidence interval [CI] 0.20–0.58 %; P < 0.01), mortality (OR 0.31; 95 % CI 0.15 %–0.64 %; P < 0.01), and stoma creation (OR 0.19; 95 % CI 0.12–0.28 %; P < 0.01). Although SEMS placement was significantly associated with a higher risk of perforation of the large bowel (OR 5.25 95 % CI 2.00–13.78 %; P < 0.01) and late complications (OR 1.94; 95 % CI 0.90–4.19 %; P = 0.03), it also contributed significantly to better long-term survival (hazard ratio 0.46; 95 % CI 0.31–0.68 %; P < 0.01). Conclusions: Compared with surgical intervention, SEMS could provide feasible palliation for patients with bowel obstructions and unresectable CRC, because of their acceptable morbidity rates and better patient prognoses.

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