Abstract
We use cell traction force (CTF) to self-fold flat microplates into diverse three-dimensional (3D) cell-laden microstructures (Figure 1). Cells were selectively cultured onto the flat microfabricated plates. Immediately after detaching the plates from the glass substrate, the plates were lifted and folded up into the 3D microstructures due to the CTF caused by stretched cells that adhered between two plates. We achieved precise folding angles between the folding microplate and glass substrate by producing a flexible joint between the plates. Using the microplates with the flexible joint, we also achieved batch process of self-folding 3D cell-laden microstructures. In addition, we succeed to produce micro-flapping structures using cardiomyocytes as an actuator.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) |
| Pages | 72-75 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2012 |
| Externally published | Yes |
| Event | 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France Duration: 2012 Jan 29 → 2012 Feb 2 |
Other
| Other | 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 |
|---|---|
| Country | France |
| City | Paris |
| Period | 12/1/29 → 12/2/2 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Mechanical Engineering
- Condensed Matter Physics
- Electronic, Optical and Magnetic Materials
Cite this
Self-folding cell origami : Batch process of self-folding 3D cell-laden microstructures actuated by cell traction force. / Kuribayashi-Shigetomi, K.; Onoe, Hiroaki; Takeuchi, S.
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2012. p. 72-75 6170096.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Self-folding cell origami
T2 - Batch process of self-folding 3D cell-laden microstructures actuated by cell traction force
AU - Kuribayashi-Shigetomi, K.
AU - Onoe, Hiroaki
AU - Takeuchi, S.
PY - 2012
Y1 - 2012
N2 - We use cell traction force (CTF) to self-fold flat microplates into diverse three-dimensional (3D) cell-laden microstructures (Figure 1). Cells were selectively cultured onto the flat microfabricated plates. Immediately after detaching the plates from the glass substrate, the plates were lifted and folded up into the 3D microstructures due to the CTF caused by stretched cells that adhered between two plates. We achieved precise folding angles between the folding microplate and glass substrate by producing a flexible joint between the plates. Using the microplates with the flexible joint, we also achieved batch process of self-folding 3D cell-laden microstructures. In addition, we succeed to produce micro-flapping structures using cardiomyocytes as an actuator.
AB - We use cell traction force (CTF) to self-fold flat microplates into diverse three-dimensional (3D) cell-laden microstructures (Figure 1). Cells were selectively cultured onto the flat microfabricated plates. Immediately after detaching the plates from the glass substrate, the plates were lifted and folded up into the 3D microstructures due to the CTF caused by stretched cells that adhered between two plates. We achieved precise folding angles between the folding microplate and glass substrate by producing a flexible joint between the plates. Using the microplates with the flexible joint, we also achieved batch process of self-folding 3D cell-laden microstructures. In addition, we succeed to produce micro-flapping structures using cardiomyocytes as an actuator.
UR - http://www.scopus.com/inward/record.url?scp=84860481695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860481695&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2012.6170096
DO - 10.1109/MEMSYS.2012.6170096
M3 - Conference contribution
AN - SCOPUS:84860481695
SN - 9781467303248
SP - 72
EP - 75
BT - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ER -