TY - GEN
T1 - Self-organized 3D bridging of cardiomyocytes toward creation of ultra small cell-driven pumps integrated in microstructure
AU - Tanaka, Y.
AU - Yamashita, T.
AU - Vogel, V.
N1 - Funding Information:
The authors are grateful for financial support from bilateral program, Grants-in-Aid for Young Scientist (A) (25709081 and 21681019), Challenging Exploratory Research (15K13919 and 23651133), and Leading-edge Research Infrastructure Program, Postdoctoral Fellowship for Research Abroad (T. Yamashita), JSPS, Japan. The authors also thank financial support from TATEISI Science and Technology Foundation, OMRON, Japan. The author also thanks Dr. H. R. Ueda in RIKEN, Japan for useful discussions.
Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - We investigated the self-organized bridging phenomenon of cardiomyocytes in microgroove structure. Cardiomyocytes formed several bridges inside the microgrooves. The bridging tissues were completely apart from the bottom of microgroove, and surprisingly, the both edges were connecting to the micro-groove walls at middle heights. Bridging of cardiomyocytes was most observed when the groove aspect ratio is around 1 regardless of the depth of the microgrooves, suggesting that cell-generated force has a major role in bridge formation. Our semi-quantitative observation gives an insight to the self tissue organization process in microstructures and would be useful criterion to design ultra small bio-micropumps.
AB - We investigated the self-organized bridging phenomenon of cardiomyocytes in microgroove structure. Cardiomyocytes formed several bridges inside the microgrooves. The bridging tissues were completely apart from the bottom of microgroove, and surprisingly, the both edges were connecting to the micro-groove walls at middle heights. Bridging of cardiomyocytes was most observed when the groove aspect ratio is around 1 regardless of the depth of the microgrooves, suggesting that cell-generated force has a major role in bridge formation. Our semi-quantitative observation gives an insight to the self tissue organization process in microstructures and would be useful criterion to design ultra small bio-micropumps.
KW - Bridging
KW - Cardiomyocyte
KW - Microgroove
KW - Self-organization
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M3 - Conference contribution
AN - SCOPUS:84983371870
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1773
EP - 1775
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -