Self-organized 3D bridging of cardiomyocytes toward creation of ultra small cell-driven pumps integrated in microstructure

Y. Tanaka, Tadahiro Yamashita, V. Vogel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated the self-organized bridging phenomenon of cardiomyocytes in microgroove structure. Cardiomyocytes formed several bridges inside the microgrooves. The bridging tissues were completely apart from the bottom of microgroove, and surprisingly, the both edges were connecting to the micro-groove walls at middle heights. Bridging of cardiomyocytes was most observed when the groove aspect ratio is around 1 regardless of the depth of the microgrooves, suggesting that cell-generated force has a major role in bridge formation. Our semi-quantitative observation gives an insight to the self tissue organization process in microstructures and would be useful criterion to design ultra small bio-micropumps.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1773-1775
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015 Jan 1
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

Keywords

  • Bridging
  • Cardiomyocyte
  • Microgroove
  • Self-organization

ASJC Scopus subject areas

  • Control and Systems Engineering

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