Semi-quantitative assessment of oral cavity squamous cell carcinoma using 201Tl SPECT for evaluating effectiveness of preoperative radiotherapy

Aya Suzuki, Takashi Togawa, Junpei Kuyama, Tadaki Nakahara, Toshinao Takenouchi, Kazuo Hatano, Ken Omura

Research output: Contribution to journalArticle

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Abstract

The aim of this study is to reveal the usefulness of semi-quantitative assessment using 201Tl chloride (Tl) single photon emission computed tomography (SPECT) (Tl SPECT) to evaluate the effectiveness of radiotherapy in 15 patients with oral cavity squamous cell carcinma (SCC). Fifteen patients were diagnosed with SCC by biopsy. All 15 patients enrolled in this study were planned to undergo preoperative radiotherapy with or without chemotherapy using carboplatin (CBDCA) and received reduction operation. Tl SPECTs were performed 15 minutes after intravenous administration of 111 MBq 201Tl chloride. Regions of Interest (ROI) were set up around tumor (T), and non-lesion (N) at the part of contralateral scalp at the height of the cerebellum. The ratios of mean counts in ROI of the tumor to those in non-lesion were measured as pre- and post-treatment T/N ratios (pre T/N, post T/N). Furthermore, reduction rate (RR) was obtained by calculating [(pre T/N - post T/N)/(pre T/N)] × 100%. Each parameter (pre T/N, post T/N, and RR) was compared to histopathological grade of surgical specimen based on the Oboshi and Shimosato classification (grade I-IV). RR showed significantly higher values in grade III and IV than in grade I and II (p = 0.0008). In conclusion, semi-quantitative assessment using Tl SPECT, especially calculating RR, is useful to evaluate the effectiveness of preoperative radiotherapy.

Original languageEnglish
Pages (from-to)433-441
Number of pages9
JournalAnnals of Nuclear Medicine
Volume18
Issue number5
Publication statusPublished - 2004 Jul
Externally publishedYes

Fingerprint

Single-Photon Emission-Computed Tomography
Mouth
Squamous Cell Carcinoma
Radiotherapy
Carboplatin
Chlorides
Epithelial Cells
Scalp
Intravenous Administration
Cerebellum
Neoplasms
Biopsy
Drug Therapy
Therapeutics

Keywords

  • Tl SPECT
  • Oral cavity squamous cell carcinoma
  • Radiotherapy
  • Semi-quantitative evaluation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Semi-quantitative assessment of oral cavity squamous cell carcinoma using 201Tl SPECT for evaluating effectiveness of preoperative radiotherapy. / Suzuki, Aya; Togawa, Takashi; Kuyama, Junpei; Nakahara, Tadaki; Takenouchi, Toshinao; Hatano, Kazuo; Omura, Ken.

In: Annals of Nuclear Medicine, Vol. 18, No. 5, 07.2004, p. 433-441.

Research output: Contribution to journalArticle

Suzuki, Aya ; Togawa, Takashi ; Kuyama, Junpei ; Nakahara, Tadaki ; Takenouchi, Toshinao ; Hatano, Kazuo ; Omura, Ken. / Semi-quantitative assessment of oral cavity squamous cell carcinoma using 201Tl SPECT for evaluating effectiveness of preoperative radiotherapy. In: Annals of Nuclear Medicine. 2004 ; Vol. 18, No. 5. pp. 433-441.
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