Sensitive detection of alkyne-terminated hydrophobic drug by surface-enhanced stimulated Raman scattering in cetyltrimethylammonium bromide-coated gold nanorod suspensions

Takaha Mizuguchi, Mutsuo Nuriya, Masato Yasui, Takanori Iino, Yasuyuki Ozeki, Toshiharu Saiki

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate the sensitive detection of alkyne-terminated ethinylestradiol (EE2) in a cetyltrimethylammonium bromide (CTAB)-coated gold nanorod (AuNR) suspension by surface-enhanced stimulated Raman scattering (SRS). Since alkynes show a distinct Raman peak at the silent wavenumber region, EE2 can be detected by obtaining the alkyne-specific SRS signals. Here we find the CTAB coating uniformly adsorbs the hydrophobic EE2 and enables it to exist in the plasmonic hotspot of AuNRs without the alkyne binding to AuNR surfaces. As a result, ensemble-averaged plasmonic enhancement using a CTAB-coated AuNR suspension improved the detection limit for SRS signals from EE2 by one order of magnitude.

Original languageEnglish
Article number032003
JournalApplied Physics Express
Volume14
Issue number3
DOIs
Publication statusPublished - 2021 Mar

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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