Sensitivity analysis of ectopic electrical activity in the pulmonary vein myocardium

Hitomi I. Sano, Yuichiro Tanaka, Yasuhiro Naito, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The pulmonary vein contains a myocardial layer that is capable of generating spontaneous or triggered action potentials. Although the electrophysiological and pharmacological characteristics of the pulmonary vein myocardium have been compiled in various studies, a comprehensive understanding of the spontaneous action potentials generated in the myocardial layer has yet to be presented. Here we integrated the electrophysiological properties of the pulmonary vein myocardial layer using a Guinea pig ventricular cell model. Based on the preceding research, which reported that approximately half of the isolated pulmonary vein myocardial layer exhibited spontaneous action potentials and the remaining half was quiescent, we constructed various combinations of the pulmonary vein myocardial models to represent variations of the action potential tracings. As a result, we predicted that the spontaneous action potentials, including burst-like action potentials, are observed with varying currents of the relative densities of Na+ (INa), L-type Ca2+ (ICaL), inwardly rectifying K+ (IK1), rapid component of delayed rectifying K+ (IKr), and ACh-activated K+ (IKACh).

Original languageEnglish
Title of host publicationComputing in Cardiology
PublisherIEEE Computer Society
Pages861-864
Number of pages4
Volume42
ISBN (Print)9781509006854
DOIs
Publication statusPublished - 2016 Feb 16
Event42nd Computing in Cardiology Conference, CinC 2015 - Nice, France
Duration: 2015 Sep 62015 Sep 9

Other

Other42nd Computing in Cardiology Conference, CinC 2015
CountryFrance
CityNice
Period15/9/615/9/9

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Computer Science(all)

Cite this

Sano, H. I., Tanaka, Y., Naito, Y., & Tomita, M. (2016). Sensitivity analysis of ectopic electrical activity in the pulmonary vein myocardium. In Computing in Cardiology (Vol. 42, pp. 861-864). [7411047] IEEE Computer Society. https://doi.org/10.1109/CIC.2015.7411047