Sensorimotor event-related desynchronization represents the excitability of human spinal motoneurons

M. Takemi, Y. Masakado, Meigen Liu, Junichi Ushiba

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Amplitudes of mu and beta (7-26. Hz) oscillations measured by electroencephalography over the sensorimotor areas are suppressed during motor imagery as well as during voluntary movements. This phenomenon is referred to as event-related desynchronization (ERD) and is known to reflect motor cortical excitability. The increased motor cortical excitability associated with ERD during hand motor imagery would induce a descending cortical volley to spinal motoneurons, resulting in facilitation of spinal motoneuronal excitability. Therefore, in the present study, we tested the association of ERD during motor imagery with the excitability of spinal motoneurons in 15 healthy participants. Spinal excitability was tested using the F-wave recorded from the right abductor pollicis brevis muscle. The F-wave results from antidromic activation of spinal motoneurons and is induced by peripheral nerve stimulation. Participants performed 5. s of motor imagery of right thumb abduction following 7. s of rest. The right median nerve was stimulated at wrist level when the ERD magnitude of the contralateral hand sensorimotor area exceeded predetermined thresholds during motor imagery. The results showed ERD magnitude during hand motor imagery was associated with an increase in F-wave persistence, but not with the response average of F-wave amplitude or F-wave latency. These findings suggest that the ERD magnitude may be a biomarker representing increases in the excitability of both cortical and spinal levels.

Original languageEnglish
Pages (from-to)58-67
Number of pages10
JournalNeuroscience
Volume297
DOIs
Publication statusPublished - 2015 Jun 5

Fingerprint

Imagery (Psychotherapy)
Motor Neurons
Hand
Median Nerve
Thumb
Wrist
Peripheral Nerves
Electroencephalography
Healthy Volunteers
Biomarkers
Muscles
Cortical Excitability

Keywords

  • Cortical oscillations
  • Electroencephalography
  • F-wave
  • Motor imagery
  • Spinal excitability

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sensorimotor event-related desynchronization represents the excitability of human spinal motoneurons. / Takemi, M.; Masakado, Y.; Liu, Meigen; Ushiba, Junichi.

In: Neuroscience, Vol. 297, 05.06.2015, p. 58-67.

Research output: Contribution to journalArticle

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