Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer

Masayuki Tomifuji, Akihiro Shiotani, Hirofumi Fujii, Koji Araki, Koichiro Saito, Koji Inagaki, Makio Mukai, Yuukou Kitagawa, Kaoru Ogawa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Sentinel nodes (SNs) are the lymph nodes that directly receive lymphatic flow from a primary cancer lesion. The SN concept implies that lymphatic metastasis initially occurs at SNs. SN navigation surgery can be introduced for cancers in which the SN concept is established. In SN navigation surgery, lymph node dissection beyond SNs can be omitted if SNs are metastasis free. Although the SN concept has been investigated frequently for oral and oropharyngeal cancer, it has so far been investigated less for laryngeal and hypopharyngeal cancer. In this study, we investigated whether the SN concept is applicable for laryngeal and hypopharyngeal cancer. Methods: Twenty patients with T2-T4 and clinically N0 laryngeal and hypopharyngeal cancer were recruited. 99mTc-phytate was injected into several sites surrounding the tumor on the day before surgery. Lymphoscintigrams were acquired from at least two different viewpoints. SNs were surveyed intraoperatively, and neck dissections including at least levels II, III, and IV were performed. Results: SNs had occult metastases in five cases. In the remaining 15 cases, neither SNs nor other lymph nodes contained metastases, consistent with the SN concept. There was one false-negative case showing delayed nodal metastasis 2 years after initial surgery. The overall accuracy of the SN concept was 95%. Conclusion: Our study shows that SN biopsy is a reliable strategy to determine correct lymph node status in N0 laryngeal and hypopharyngeal cancer. SN detection was valuable in evaluating the need for neck dissection, whether ipsilaterally or bilaterally.

Original languageEnglish
Pages (from-to)2568-2575
Number of pages8
JournalAnnals of Surgical Oncology
Volume15
Issue number9
DOIs
Publication statusPublished - 2008 Sep

Fingerprint

Hypopharyngeal Neoplasms
Laryngeal Neoplasms
Neoplasm Metastasis
cyhalothrin
Neck Dissection
Lymph Nodes
Oropharyngeal Neoplasms
Lymphatic Metastasis

Keywords

  • Hypopharyngeal cancer
  • Laryngeal cancer
  • Lymphoscintigraphy
  • Occult metastasis
  • Sentinel node
  • Sentinel node concept

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer. / Tomifuji, Masayuki; Shiotani, Akihiro; Fujii, Hirofumi; Araki, Koji; Saito, Koichiro; Inagaki, Koji; Mukai, Makio; Kitagawa, Yuukou; Ogawa, Kaoru.

In: Annals of Surgical Oncology, Vol. 15, No. 9, 09.2008, p. 2568-2575.

Research output: Contribution to journalArticle

Tomifuji, M, Shiotani, A, Fujii, H, Araki, K, Saito, K, Inagaki, K, Mukai, M, Kitagawa, Y & Ogawa, K 2008, 'Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer', Annals of Surgical Oncology, vol. 15, no. 9, pp. 2568-2575. https://doi.org/10.1245/s10434-008-0008-x
Tomifuji M, Shiotani A, Fujii H, Araki K, Saito K, Inagaki K et al. Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer. Annals of Surgical Oncology. 2008 Sep;15(9):2568-2575. https://doi.org/10.1245/s10434-008-0008-x
Tomifuji, Masayuki ; Shiotani, Akihiro ; Fujii, Hirofumi ; Araki, Koji ; Saito, Koichiro ; Inagaki, Koji ; Mukai, Makio ; Kitagawa, Yuukou ; Ogawa, Kaoru. / Sentinel node concept in clinically N0 laryngeal and hypopharyngeal cancer. In: Annals of Surgical Oncology. 2008 ; Vol. 15, No. 9. pp. 2568-2575.
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AU - Araki, Koji

AU - Saito, Koichiro

AU - Inagaki, Koji

AU - Mukai, Makio

AU - Kitagawa, Yuukou

AU - Ogawa, Kaoru

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AB - Background: Sentinel nodes (SNs) are the lymph nodes that directly receive lymphatic flow from a primary cancer lesion. The SN concept implies that lymphatic metastasis initially occurs at SNs. SN navigation surgery can be introduced for cancers in which the SN concept is established. In SN navigation surgery, lymph node dissection beyond SNs can be omitted if SNs are metastasis free. Although the SN concept has been investigated frequently for oral and oropharyngeal cancer, it has so far been investigated less for laryngeal and hypopharyngeal cancer. In this study, we investigated whether the SN concept is applicable for laryngeal and hypopharyngeal cancer. Methods: Twenty patients with T2-T4 and clinically N0 laryngeal and hypopharyngeal cancer were recruited. 99mTc-phytate was injected into several sites surrounding the tumor on the day before surgery. Lymphoscintigrams were acquired from at least two different viewpoints. SNs were surveyed intraoperatively, and neck dissections including at least levels II, III, and IV were performed. Results: SNs had occult metastases in five cases. In the remaining 15 cases, neither SNs nor other lymph nodes contained metastases, consistent with the SN concept. There was one false-negative case showing delayed nodal metastasis 2 years after initial surgery. The overall accuracy of the SN concept was 95%. Conclusion: Our study shows that SN biopsy is a reliable strategy to determine correct lymph node status in N0 laryngeal and hypopharyngeal cancer. SN detection was valuable in evaluating the need for neck dissection, whether ipsilaterally or bilaterally.

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