Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Contribution to conferencePaper

Abstract

We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

Original languageEnglish
Pages4996-4997
Number of pages2
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

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Keywords

  • Bioactive compound
  • Cationic surface
  • Ion exchange chromatography
  • Living radical polymerization
  • Thermoresponsive surface

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H., & Okano, T. (2006). Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces. 4996-4997. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.