Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages4996-4997
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Fingerprint

Copolymers
Silica
Atom transfer radical polymerization
Brushes
Coulomb interactions
Temperature

Keywords

  • Bioactive compound
  • Cationic surface
  • Ion exchange chromatography
  • Living radical polymerization
  • Thermoresponsive surface

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H., & Okano, T. (2006). Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 4996-4997)

Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces. / Nagase, Kenichi; Kobayashi, Jun; Kikuchi, Akihiko; Akiyama, Yoshikatsu; Kanazawa, Hideko; Okano, Teruo.

Polymer Preprints, Japan. Vol. 55 2. ed. 2006. p. 4996-4997.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nagase, K, Kobayashi, J, Kikuchi, A, Akiyama, Y, Kanazawa, H & Okano, T 2006, Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces. in Polymer Preprints, Japan. 2 edn, vol. 55, pp. 4996-4997, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 06/9/20.
Nagase K, Kobayashi J, Kikuchi A, Akiyama Y, Kanazawa H, Okano T. Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces. In Polymer Preprints, Japan. 2 ed. Vol. 55. 2006. p. 4996-4997
Nagase, Kenichi ; Kobayashi, Jun ; Kikuchi, Akihiko ; Akiyama, Yoshikatsu ; Kanazawa, Hideko ; Okano, Teruo. / Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces. Polymer Preprints, Japan. Vol. 55 2. ed. 2006. pp. 4996-4997
@inproceedings{b2697817fc944f598b7de6e04bd6e615,
title = "Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces",
abstract = "We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.",
keywords = "Bioactive compound, Cationic surface, Ion exchange chromatography, Living radical polymerization, Thermoresponsive surface",
author = "Kenichi Nagase and Jun Kobayashi and Akihiko Kikuchi and Yoshikatsu Akiyama and Hideko Kanazawa and Teruo Okano",
year = "2006",
language = "English",
volume = "55",
pages = "4996--4997",
booktitle = "Polymer Preprints, Japan",
edition = "2",

}

TY - GEN

T1 - Separation of bioactive compounds on thermoresponsive cationic copolymer-modified surfaces

AU - Nagase, Kenichi

AU - Kobayashi, Jun

AU - Kikuchi, Akihiko

AU - Akiyama, Yoshikatsu

AU - Kanazawa, Hideko

AU - Okano, Teruo

PY - 2006

Y1 - 2006

N2 - We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

AB - We prepared poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (poly(IPAAm-co-DMAEMA))-grafted brush surfaces on silica beads as Chromatographic matrices by surface-initiated atom transfer radical polymerization (ATRP). Utilizing poly(IPAAm-co-DMAEMA)-grafted silica beads as column matrixes, temperature-dependent elution profiles of anionic bioactive compounds were examined at various temperatures. The effect of electrostatic interaction on retention behavior of various types of anionic bioactive compounds was also discussed.

KW - Bioactive compound

KW - Cationic surface

KW - Ion exchange chromatography

KW - Living radical polymerization

KW - Thermoresponsive surface

UR - http://www.scopus.com/inward/record.url?scp=33846121650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846121650&partnerID=8YFLogxK

M3 - Conference contribution

VL - 55

SP - 4996

EP - 4997

BT - Polymer Preprints, Japan

ER -