Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system

Kazunari Yoshida, Shinichi Kohsaka, Takeshi Idei, Seiji Nii, Mitsuhiro Otani, Shigeo Toya, Yasuzo Tsukada

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalNeuroscience Letters
Volume66
Issue number2
DOIs
Publication statusPublished - 1986 May 15

Keywords

  • deafferentation
  • hippocampus
  • neurotrophic factor
  • rat
  • tissue culture

ASJC Scopus subject areas

  • Neuroscience(all)

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