Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

Haruhiko Siomi, Hisatoshi Shida, Seok Hyun Nam, Tetsuya Nosaka, Masatoshi Maki, Masakazu Hatanaka

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

The posttranscriptional regulator (p27x-III) of human T cell leukemia virus type I (HTLV-I) is located predominantly in the cell nucleolus. A highly basic aminoterminal sequence (NH2-Met-Pro-Lys-Thr-Arg-Arg-Arg-Pro-Arg-Arg-Ser-Gln-Arg-Lys-Arg-Pro-Pro-Thr-Pro) in this protein, when fused to the amino termini of β-galactosidase and p40x of HTLV-I, acts as an autonomous signal capable of directing the hybrid proteins to the cell nucleolus.

Original languageEnglish
Pages (from-to)197-209
Number of pages13
JournalCell
Volume55
Issue number2
DOIs
Publication statusPublished - 1988 Oct 21
Externally publishedYes

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Cell Nucleolus
Human T-lymphotropic virus 1
T-cells
Viral RNA
Viruses
Galactosidases
Processing
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing. / Siomi, Haruhiko; Shida, Hisatoshi; Nam, Seok Hyun; Nosaka, Tetsuya; Maki, Masatoshi; Hatanaka, Masakazu.

In: Cell, Vol. 55, No. 2, 21.10.1988, p. 197-209.

Research output: Contribution to journalArticle

Siomi, Haruhiko ; Shida, Hisatoshi ; Nam, Seok Hyun ; Nosaka, Tetsuya ; Maki, Masatoshi ; Hatanaka, Masakazu. / Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing. In: Cell. 1988 ; Vol. 55, No. 2. pp. 197-209.
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