Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

Haruhiko Siomi, Hisatoshi Shida, Seok Hyun Nam, Tetsuya Nosaka, Masatoshi Maki, Masakazu Hatanaka

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

The posttranscriptional regulator (p27x-III) of human T cell leukemia virus type I (HTLV-I) is located predominantly in the cell nucleolus. A highly basic aminoterminal sequence (NH2-Met-Pro-Lys-Thr-Arg-Arg-Arg-Pro-Arg-Arg-Ser-Gln-Arg-Lys-Arg-Pro-Pro-Thr-Pro) in this protein, when fused to the amino termini of β-galactosidase and p40x of HTLV-I, acts as an autonomous signal capable of directing the hybrid proteins to the cell nucleolus.

Original languageEnglish
Pages (from-to)197-209
Number of pages13
JournalCell
Volume55
Issue number2
DOIs
Publication statusPublished - 1988 Oct 21
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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