Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction

S. Goto, Y. Kawai, S. Handa, S. Abe, E. Takahashi, K. Watanabe, S. Hori, Y. Ikeda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Plasminogen activator inhibitor-1 (PAI-1), which is secreted from vascular endothelial cells, plays an important role in regulating fibrinolysis. We measured the plasma concentrations of tissue-type plasminogen activator (t-PA), PAI-1 and t-PA PAI complex before and serially after thrombolytic therapy for acute myocardial infarction to clarify the relationship between thrombolytic therapy and PAI-1. Plasma concentrations of t-PA, PAI-1 and t-PA PAI complex before thrombolytic therapy were 11.6 ± 5.5, 27.0 ± 13.0 and 7.3 ± 5.4 ng/ml, respectively. t-PA and t-PA PAI complex increased to 25.0 ± 5.3 and 14.3 ± 6.5 ng/ml immediately after drug administration; however, the level of PAI-1 decreased slightly immediately after thrombolytic therapy. The PAI-1 level increased again several hours after therapy. especially in patients showing apparently successful reperfusion. All values returned to normal 4-7 days after thrombolytic therapy. Not only augmented antifibrinolytic activity suggested by increased PAI-1 but also augmented fibrinolytic activity suggested by increased t-PA was observed in patients with acute myocardial infarction. These abnormal findings persisted several days after coronary thrombolytic therapy.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalCardiology
Volume82
Issue number4
Publication statusPublished - 1993

Fingerprint

Plasminogen Activator Inhibitor 1
Thrombolytic Therapy
Myocardial Infarction
Plasminogen Activators
Antifibrinolytic Agents
Fibrinolysis
Tissue Plasminogen Activator
Reperfusion
Endothelial Cells

Keywords

  • Coronary thrombolysis
  • PAI-1
  • t-PA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Goto, S., Kawai, Y., Handa, S., Abe, S., Takahashi, E., Watanabe, K., ... Ikeda, Y. (1993). Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction. Cardiology, 82(4), 280-285.

Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction. / Goto, S.; Kawai, Y.; Handa, S.; Abe, S.; Takahashi, E.; Watanabe, K.; Hori, S.; Ikeda, Y.

In: Cardiology, Vol. 82, No. 4, 1993, p. 280-285.

Research output: Contribution to journalArticle

Goto, S, Kawai, Y, Handa, S, Abe, S, Takahashi, E, Watanabe, K, Hori, S & Ikeda, Y 1993, 'Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction', Cardiology, vol. 82, no. 4, pp. 280-285.
Goto, S. ; Kawai, Y. ; Handa, S. ; Abe, S. ; Takahashi, E. ; Watanabe, K. ; Hori, S. ; Ikeda, Y. / Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction. In: Cardiology. 1993 ; Vol. 82, No. 4. pp. 280-285.
@article{31321dd835eb47e08e5b840f5c1195dd,
title = "Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction",
abstract = "Plasminogen activator inhibitor-1 (PAI-1), which is secreted from vascular endothelial cells, plays an important role in regulating fibrinolysis. We measured the plasma concentrations of tissue-type plasminogen activator (t-PA), PAI-1 and t-PA PAI complex before and serially after thrombolytic therapy for acute myocardial infarction to clarify the relationship between thrombolytic therapy and PAI-1. Plasma concentrations of t-PA, PAI-1 and t-PA PAI complex before thrombolytic therapy were 11.6 ± 5.5, 27.0 ± 13.0 and 7.3 ± 5.4 ng/ml, respectively. t-PA and t-PA PAI complex increased to 25.0 ± 5.3 and 14.3 ± 6.5 ng/ml immediately after drug administration; however, the level of PAI-1 decreased slightly immediately after thrombolytic therapy. The PAI-1 level increased again several hours after therapy. especially in patients showing apparently successful reperfusion. All values returned to normal 4-7 days after thrombolytic therapy. Not only augmented antifibrinolytic activity suggested by increased PAI-1 but also augmented fibrinolytic activity suggested by increased t-PA was observed in patients with acute myocardial infarction. These abnormal findings persisted several days after coronary thrombolytic therapy.",
keywords = "Coronary thrombolysis, PAI-1, t-PA",
author = "S. Goto and Y. Kawai and S. Handa and S. Abe and E. Takahashi and K. Watanabe and S. Hori and Y. Ikeda",
year = "1993",
language = "English",
volume = "82",
pages = "280--285",
journal = "Cardiology (Switzerland)",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Serial changes in plasma concentration of plasminogen activator inhibitor- 1 before and serially after thrombolytic therapy for acute myocardial infarction

AU - Goto, S.

AU - Kawai, Y.

AU - Handa, S.

AU - Abe, S.

AU - Takahashi, E.

AU - Watanabe, K.

AU - Hori, S.

AU - Ikeda, Y.

PY - 1993

Y1 - 1993

N2 - Plasminogen activator inhibitor-1 (PAI-1), which is secreted from vascular endothelial cells, plays an important role in regulating fibrinolysis. We measured the plasma concentrations of tissue-type plasminogen activator (t-PA), PAI-1 and t-PA PAI complex before and serially after thrombolytic therapy for acute myocardial infarction to clarify the relationship between thrombolytic therapy and PAI-1. Plasma concentrations of t-PA, PAI-1 and t-PA PAI complex before thrombolytic therapy were 11.6 ± 5.5, 27.0 ± 13.0 and 7.3 ± 5.4 ng/ml, respectively. t-PA and t-PA PAI complex increased to 25.0 ± 5.3 and 14.3 ± 6.5 ng/ml immediately after drug administration; however, the level of PAI-1 decreased slightly immediately after thrombolytic therapy. The PAI-1 level increased again several hours after therapy. especially in patients showing apparently successful reperfusion. All values returned to normal 4-7 days after thrombolytic therapy. Not only augmented antifibrinolytic activity suggested by increased PAI-1 but also augmented fibrinolytic activity suggested by increased t-PA was observed in patients with acute myocardial infarction. These abnormal findings persisted several days after coronary thrombolytic therapy.

AB - Plasminogen activator inhibitor-1 (PAI-1), which is secreted from vascular endothelial cells, plays an important role in regulating fibrinolysis. We measured the plasma concentrations of tissue-type plasminogen activator (t-PA), PAI-1 and t-PA PAI complex before and serially after thrombolytic therapy for acute myocardial infarction to clarify the relationship between thrombolytic therapy and PAI-1. Plasma concentrations of t-PA, PAI-1 and t-PA PAI complex before thrombolytic therapy were 11.6 ± 5.5, 27.0 ± 13.0 and 7.3 ± 5.4 ng/ml, respectively. t-PA and t-PA PAI complex increased to 25.0 ± 5.3 and 14.3 ± 6.5 ng/ml immediately after drug administration; however, the level of PAI-1 decreased slightly immediately after thrombolytic therapy. The PAI-1 level increased again several hours after therapy. especially in patients showing apparently successful reperfusion. All values returned to normal 4-7 days after thrombolytic therapy. Not only augmented antifibrinolytic activity suggested by increased PAI-1 but also augmented fibrinolytic activity suggested by increased t-PA was observed in patients with acute myocardial infarction. These abnormal findings persisted several days after coronary thrombolytic therapy.

KW - Coronary thrombolysis

KW - PAI-1

KW - t-PA

UR - http://www.scopus.com/inward/record.url?scp=0027260903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027260903&partnerID=8YFLogxK

M3 - Article

VL - 82

SP - 280

EP - 285

JO - Cardiology (Switzerland)

JF - Cardiology (Switzerland)

SN - 0008-6312

IS - 4

ER -