Serotonergic neurotransmission in the living human brain: A positron emission tomography study using [11C]dasb and [11C]WAY100635 in young healthy men

Harumasa Takano, Hiroshi Ito, Hidehiko Takahashi, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Tatsui Otsuka, Motoichiro Kato, Tetsuya Suhara

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The central serotonergic (5-HT) system is closely involved in regulating various mental functions such as mood and emotion. In this system, the serotonin transporter (5-HTT) and the 5-HT1A receptor play important roles in the pathophysiology and treatment of mood and anxiety disorders. However, only a few integrated databases have considered the intraindividual relationship between pre- and postsynaptic serotonergic transmission. In the present study, we constructed a database of 5-HTT and 5-HT1A receptors using positron emission tomography (PET) with [11C]DASB and [11C]WAY100635, respectively. Seventeen healthy young men participated in this study. After anatomic standardization of original images, BPND was calculated on a voxel-by-voxel basis using reference tissue methods. The highest binding to 5-HTT was observed in the dorsal raphe nucleus, striatum, and thalamus; moderate binding, in the insula and cingulate cortex; and very low binding, in the cerebral neocortex. In contrast, the highest binding to 5-HT1A receptors was seen in the hippocampal regions, insula, neocortical regions, and dorsal raphe nucleus, and very low binding was found in the thalamus and basal ganglia. These distribution patterns were in agreement with those reported in human postmortem studies and previous PET investigations. In addition, exploratory analysis indicated significant negative correlations between the BPND values with both radiotracers in certain regions of the brain, such as the cingulate, insula, and frontal, temporal and parietal cortices (Pearson's correlation, P < 0.05). These databases facilitate the understanding of the regional distribution of serotonergic neurotransmission function in the living human brain and the pathophysiology of various neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)624-633
Number of pages10
JournalSynapse
Volume65
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Fingerprint

Receptor, Serotonin, 5-HT1A
Synaptic Transmission
Positron-Emission Tomography
Databases
Thalamus
Brain
Serotonin Plasma Membrane Transport Proteins
Parietal Lobe
Neocortex
Gyrus Cinguli
Frontal Lobe
Temporal Lobe
Basal Ganglia
Anxiety Disorders
Mood Disorders
Serotonin
Emotions
Dorsal Raphe Nucleus
Therapeutics

Keywords

  • Normal database
  • Positron emission tomography
  • Serotonin
  • Serotonin 1A receptor
  • Serotonin transporter

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Serotonergic neurotransmission in the living human brain : A positron emission tomography study using [11C]dasb and [11C]WAY100635 in young healthy men. / Takano, Harumasa; Ito, Hiroshi; Takahashi, Hidehiko; Arakawa, Ryosuke; Okumura, Masaki; Kodaka, Fumitoshi; Otsuka, Tatsui; Kato, Motoichiro; Suhara, Tetsuya.

In: Synapse, Vol. 65, No. 7, 07.2011, p. 624-633.

Research output: Contribution to journalArticle

Takano, H, Ito, H, Takahashi, H, Arakawa, R, Okumura, M, Kodaka, F, Otsuka, T, Kato, M & Suhara, T 2011, 'Serotonergic neurotransmission in the living human brain: A positron emission tomography study using [11C]dasb and [11C]WAY100635 in young healthy men', Synapse, vol. 65, no. 7, pp. 624-633. https://doi.org/10.1002/syn.20883
Takano, Harumasa ; Ito, Hiroshi ; Takahashi, Hidehiko ; Arakawa, Ryosuke ; Okumura, Masaki ; Kodaka, Fumitoshi ; Otsuka, Tatsui ; Kato, Motoichiro ; Suhara, Tetsuya. / Serotonergic neurotransmission in the living human brain : A positron emission tomography study using [11C]dasb and [11C]WAY100635 in young healthy men. In: Synapse. 2011 ; Vol. 65, No. 7. pp. 624-633.
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