TY - JOUR
T1 - Serotonin 2A receptor gene polymorphism and personality traits
T2 - No evidence for significant association
AU - Tochigi, Mamoru
AU - Umekage, Tadashi
AU - Kato, Chieko
AU - Marui, Tetsuya
AU - Otowa, Takeshi
AU - Hibino, Hiroyuki
AU - Otani, Toshiyuki
AU - Kohda, Kazuhisa
AU - Kato, Nobumasa
AU - Sasaki, Tsukasa
PY - 2005/3
Y1 - 2005/3
N2 - A number of studies have observed associations between the serotonin 2A (5-HT2A) receptor and mental disorders. Here, we investigated correlations between polymorphisms (-1438G/A and 102T/C) of the 5-HT 2A gene and personality traits in healthy Japanese volunteers (n = 239). The personality traits were evaluated using the Revised NEO Personality Inventory (NEO PI-R). The -1438G/A and 102T/C were in complete linkage disequilibrium. There was a tendency for associations between the genotype and the scores for Agreeableness, Conscientiousness and Neuroticism of the NEO PI-R (P=0.028, 0.039 and 0.062, respectively; analysis of variance, uncorrected for multiple testing). Subjects with the A/A of -1438G/A (or T/T of 102T/C) appeared to be lower in Neuroticism and higher in Conscientiousness than the rest of the subjects. However, the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R. Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits.
AB - A number of studies have observed associations between the serotonin 2A (5-HT2A) receptor and mental disorders. Here, we investigated correlations between polymorphisms (-1438G/A and 102T/C) of the 5-HT 2A gene and personality traits in healthy Japanese volunteers (n = 239). The personality traits were evaluated using the Revised NEO Personality Inventory (NEO PI-R). The -1438G/A and 102T/C were in complete linkage disequilibrium. There was a tendency for associations between the genotype and the scores for Agreeableness, Conscientiousness and Neuroticism of the NEO PI-R (P=0.028, 0.039 and 0.062, respectively; analysis of variance, uncorrected for multiple testing). Subjects with the A/A of -1438G/A (or T/T of 102T/C) appeared to be lower in Neuroticism and higher in Conscientiousness than the rest of the subjects. However, the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R. Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits.
KW - Harm avoidance
KW - NEO PI-R
KW - Personality trait
KW - Polymorphism
KW - STAI
KW - Serotonin 2A receptor
UR - http://www.scopus.com/inward/record.url?scp=20144373527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20144373527&partnerID=8YFLogxK
U2 - 10.1097/00041444-200503000-00011
DO - 10.1097/00041444-200503000-00011
M3 - Article
C2 - 15722960
AN - SCOPUS:20144373527
SN - 0955-8829
VL - 15
SP - 67
EP - 69
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 1
ER -
