Serotonin and pancreatic duct function.

S. Naruse; A. Suzuki; H. Ishiguro; M. Kitagawa; S. B. Ko; T. Yoshikawa; A. Yamamoto; H. Hamada; T. Hayakawa

doi:10.3346/jkms.2000.15.S.S27

Serotonin and pancreatic duct function.

S. Naruse, A. Suzuki, H. Ishiguro, M. Kitagawa, S. B. Ko, T. Yoshikawa, A. Yamamoto, H. Hamada, T. Hayakawa

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

Original language	English
Pages (from-to)	S27-28
Journal	Journal of Korean medical science
Volume	15 Suppl
DOIs	https://doi.org/10.3346/jkms.2000.15.S.S27
Publication status	Published - 2000 Aug
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.3346/jkms.2000.15.S.S27

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title = "Serotonin and pancreatic duct function.",

abstract = "1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.",

author = "S. Naruse and A. Suzuki and H. Ishiguro and M. Kitagawa and Ko, {S. B.} and T. Yoshikawa and A. Yamamoto and H. Hamada and T. Hayakawa",

year = "2000",

month = aug,

doi = "10.3346/jkms.2000.15.S.S27",

language = "English",

volume = "15 Suppl",

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journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

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T1 - Serotonin and pancreatic duct function.

AU - Naruse, S.

AU - Suzuki, A.

AU - Ishiguro, H.

AU - Kitagawa, M.

AU - Ko, S. B.

AU - Yoshikawa, T.

AU - Yamamoto, A.

AU - Hamada, H.

AU - Hayakawa, T.

PY - 2000/8

Y1 - 2000/8

N2 - 1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

AB - 1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

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DO - 10.3346/jkms.2000.15.S.S27

M3 - Article

C2 - 10981503

AN - SCOPUS:17444444919

SN - 1011-8934

VL - 15 Suppl

SP - S27-28

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

ER -

Serotonin and pancreatic duct function.

Abstract

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