Serotonin and pancreatic duct function.

S. Naruse, A. Suzuki, H. Ishiguro, M. Kitagawa, Shigeru Ko, T. Yoshikawa, A. Yamamoto, H. Hamada, T. Hayakawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

Original languageEnglish
JournalJournal of Korean Medical Science
Volume15 Suppl
Publication statusPublished - 2000 Aug
Externally publishedYes

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Pancreatic Ducts
Serotonin
Intestinal Secretions
Fluids and Secretions
Receptors, Serotonin, 5-HT3
Gastrointestinal Motility
Secretin
Guinea Pigs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Naruse, S., Suzuki, A., Ishiguro, H., Kitagawa, M., Ko, S., Yoshikawa, T., ... Hayakawa, T. (2000). Serotonin and pancreatic duct function. Journal of Korean Medical Science, 15 Suppl.

Serotonin and pancreatic duct function. / Naruse, S.; Suzuki, A.; Ishiguro, H.; Kitagawa, M.; Ko, Shigeru; Yoshikawa, T.; Yamamoto, A.; Hamada, H.; Hayakawa, T.

In: Journal of Korean Medical Science, Vol. 15 Suppl, 08.2000.

Research output: Contribution to journalArticle

Naruse, S, Suzuki, A, Ishiguro, H, Kitagawa, M, Ko, S, Yoshikawa, T, Yamamoto, A, Hamada, H & Hayakawa, T 2000, 'Serotonin and pancreatic duct function.', Journal of Korean Medical Science, vol. 15 Suppl.
Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko S, Yoshikawa T et al. Serotonin and pancreatic duct function. Journal of Korean Medical Science. 2000 Aug;15 Suppl.
Naruse, S. ; Suzuki, A. ; Ishiguro, H. ; Kitagawa, M. ; Ko, Shigeru ; Yoshikawa, T. ; Yamamoto, A. ; Hamada, H. ; Hayakawa, T. / Serotonin and pancreatic duct function. In: Journal of Korean Medical Science. 2000 ; Vol. 15 Suppl.
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