Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans

M. H. Pietraszek, N. A. Choudhury, S. Baba, S. Sakaguchi, T. Hachiya, T. Urano, Y. Takada, A. Takada

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Whole blood and plasma levels of serotonin (5-hydroxytryptamine, 5-HT) as well as its uptake and spontaneous release from blood platelets were studied in 20 patients suffering from thromboangiitis obliterans (TAO, Buerger's disease) and 20 healthy subjects matched in pairs for age. Results of patients suffering from thromboangiitis obliterans differed in several ways from those of controls. Whole blood 5-HT content was significantly lower in the group of patients compared to that of the control group. It was established that patients with Buerger's disease have significantly greater plasma concentrations of free serotonin. In Buerger's disease patients, maximal platelet serotonin uptake velocity (V(max)) was significantly decreased. It was associated with the enhanced spontaneous release of 5-HT from blood platelets. We conclude that impaired platelet serotonin uptake and increased local concentration of serotonin in the vicinity of platelets in Buerger's disease may lead to platelet activation via 5-HT2 receptors, and it could be involved in the pathogenesis of thromboembolic complications.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalInternational Angiology
Volume12
Issue number1
Publication statusPublished - 1993

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Thromboangiitis Obliterans
Serotonin
Blood Platelets
Troleandomycin
Platelet Activation
Healthy Volunteers
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pietraszek, M. H., Choudhury, N. A., Baba, S., Sakaguchi, S., Hachiya, T., Urano, T., ... Takada, A. (1993). Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans. International Angiology, 12(1), 9-12.

Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans. / Pietraszek, M. H.; Choudhury, N. A.; Baba, S.; Sakaguchi, S.; Hachiya, T.; Urano, T.; Takada, Y.; Takada, A.

In: International Angiology, Vol. 12, No. 1, 1993, p. 9-12.

Research output: Contribution to journalArticle

Pietraszek, MH, Choudhury, NA, Baba, S, Sakaguchi, S, Hachiya, T, Urano, T, Takada, Y & Takada, A 1993, 'Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans', International Angiology, vol. 12, no. 1, pp. 9-12.
Pietraszek MH, Choudhury NA, Baba S, Sakaguchi S, Hachiya T, Urano T et al. Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans. International Angiology. 1993;12(1):9-12.
Pietraszek, M. H. ; Choudhury, N. A. ; Baba, S. ; Sakaguchi, S. ; Hachiya, T. ; Urano, T. ; Takada, Y. ; Takada, A. / Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans. In: International Angiology. 1993 ; Vol. 12, No. 1. pp. 9-12.
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