Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits

Susumu Jitsuki, Kiwamu Takemoto, Taisuke Kawasaki, Hirobumi Tada, Aoi Takahashi, Carine Becamel, Akane Sano, Michisuke Yuzaki, R. Suzanne Zukin, Edward B. Ziff, Helmut W. Kessels, Takuya Takahashi

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Loss of one type of sensory input can cause improved functionality of other sensory systems. Whereas this form of plasticity, cross-modal plasticity, is well established, the molecular and cellular mechanisms underlying it are still unclear. Here, we show that visual deprivation (VD) increases extracellular serotonin in the juvenile rat barrel cortex. This increase in serotonin levels facilitates synaptic strengthening at layer 4 to layer 2/3 synapses within the barrel cortex. Upon VD, whisker experience leads to trafficking of the AMPA-type glutamate receptors (AMPARs) into these synapses through the activation of ERK and increased phosphorylation of AMPAR subunit GluR1 at the juvenile age when natural whisker experience no longer induces synaptic GluR1 delivery. VD thereby leads to sharpening of the functional whisker-barrel map at layer 2/3. Thus, sensory deprivation of one modality leads to serotonin release in remaining modalities, facilitates GluR1-dependent synaptic strengthening, and refines cortical organization.

Original languageEnglish
Pages (from-to)780-792
Number of pages13
JournalNeuron
Volume69
Issue number4
DOIs
Publication statusPublished - 2011 Feb 24

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Vibrissae
Serotonin
AMPA Receptors
Glutamate Receptors
Synapses
Sensory Deprivation
Phosphorylation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Becamel, C., ... Takahashi, T. (2011). Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits. Neuron, 69(4), 780-792. https://doi.org/10.1016/j.neuron.2011.01.016

Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits. / Jitsuki, Susumu; Takemoto, Kiwamu; Kawasaki, Taisuke; Tada, Hirobumi; Takahashi, Aoi; Becamel, Carine; Sano, Akane; Yuzaki, Michisuke; Zukin, R. Suzanne; Ziff, Edward B.; Kessels, Helmut W.; Takahashi, Takuya.

In: Neuron, Vol. 69, No. 4, 24.02.2011, p. 780-792.

Research output: Contribution to journalArticle

Jitsuki, S, Takemoto, K, Kawasaki, T, Tada, H, Takahashi, A, Becamel, C, Sano, A, Yuzaki, M, Zukin, RS, Ziff, EB, Kessels, HW & Takahashi, T 2011, 'Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits', Neuron, vol. 69, no. 4, pp. 780-792. https://doi.org/10.1016/j.neuron.2011.01.016
Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C et al. Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits. Neuron. 2011 Feb 24;69(4):780-792. https://doi.org/10.1016/j.neuron.2011.01.016
Jitsuki, Susumu ; Takemoto, Kiwamu ; Kawasaki, Taisuke ; Tada, Hirobumi ; Takahashi, Aoi ; Becamel, Carine ; Sano, Akane ; Yuzaki, Michisuke ; Zukin, R. Suzanne ; Ziff, Edward B. ; Kessels, Helmut W. ; Takahashi, Takuya. / Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits. In: Neuron. 2011 ; Vol. 69, No. 4. pp. 780-792.
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