Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population

Tadashi Umekage, Mamoru Tochigi, Tetsuya Marui, Chieko Kato, Hiroyuki Hibino, Toshiyuki Otani, Kazuhisa Kohda, Nobumasa Kato, Tsukasa Sasaki

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25 Citations (Scopus)

Abstract

Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Volume337
Issue number1
DOIs
Publication statusPublished - 2003 Jan 30

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Keywords

  • Association study
  • Environment
  • Genotype
  • NEO Five-Factor Inventory (NEO-PI-R)
  • Personality
  • Serotonin transporter-linked promoter region (5-HTTLPR)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Umekage, T., Tochigi, M., Marui, T., Kato, C., Hibino, H., Otani, T., Kohda, K., Kato, N., & Sasaki, T. (2003). Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population. Neuroscience Letters, 337(1), 13-16. https://doi.org/10.1016/S0304-3940(02)01291-0