Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population

Tadashi Umekage, Mamoru Tochigi, Tetsuya Marui, Chieko Kato, Hiroyuki Hibino, Toshiyuki Otani, Kazuhisa Kohda, Nobumasa Kato, Tsukasa Sasaki

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Volume337
Issue number1
DOIs
Publication statusPublished - 2003 Jan 30
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Genetic Promoter Regions
Personality
Population
Occupations
Anxiety
Personality Inventory
Social Class
Genes
Healthy Volunteers
Nurses

Keywords

  • Association study
  • Environment
  • Genotype
  • NEO Five-Factor Inventory (NEO-PI-R)
  • Personality
  • Serotonin transporter-linked promoter region (5-HTTLPR)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population. / Umekage, Tadashi; Tochigi, Mamoru; Marui, Tetsuya; Kato, Chieko; Hibino, Hiroyuki; Otani, Toshiyuki; Kohda, Kazuhisa; Kato, Nobumasa; Sasaki, Tsukasa.

In: Neuroscience Letters, Vol. 337, No. 1, 30.01.2003, p. 13-16.

Research output: Contribution to journalArticle

Umekage, T, Tochigi, M, Marui, T, Kato, C, Hibino, H, Otani, T, Kohda, K, Kato, N & Sasaki, T 2003, 'Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population', Neuroscience Letters, vol. 337, no. 1, pp. 13-16. https://doi.org/10.1016/S0304-3940(02)01291-0
Umekage, Tadashi ; Tochigi, Mamoru ; Marui, Tetsuya ; Kato, Chieko ; Hibino, Hiroyuki ; Otani, Toshiyuki ; Kohda, Kazuhisa ; Kato, Nobumasa ; Sasaki, Tsukasa. / Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population. In: Neuroscience Letters. 2003 ; Vol. 337, No. 1. pp. 13-16.
@article{e8cd42fea3964df1a5f75089b04e4338,
title = "Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population",
abstract = "Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78{\%}) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.",
keywords = "Association study, Environment, Genotype, NEO Five-Factor Inventory (NEO-PI-R), Personality, Serotonin transporter-linked promoter region (5-HTTLPR)",
author = "Tadashi Umekage and Mamoru Tochigi and Tetsuya Marui and Chieko Kato and Hiroyuki Hibino and Toshiyuki Otani and Kazuhisa Kohda and Nobumasa Kato and Tsukasa Sasaki",
year = "2003",
month = "1",
day = "30",
doi = "10.1016/S0304-3940(02)01291-0",
language = "English",
volume = "337",
pages = "13--16",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population

AU - Umekage, Tadashi

AU - Tochigi, Mamoru

AU - Marui, Tetsuya

AU - Kato, Chieko

AU - Hibino, Hiroyuki

AU - Otani, Toshiyuki

AU - Kohda, Kazuhisa

AU - Kato, Nobumasa

AU - Sasaki, Tsukasa

PY - 2003/1/30

Y1 - 2003/1/30

N2 - Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.

AB - Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.

KW - Association study

KW - Environment

KW - Genotype

KW - NEO Five-Factor Inventory (NEO-PI-R)

KW - Personality

KW - Serotonin transporter-linked promoter region (5-HTTLPR)

UR - http://www.scopus.com/inward/record.url?scp=0037472356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037472356&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(02)01291-0

DO - 10.1016/S0304-3940(02)01291-0

M3 - Article

C2 - 12524160

AN - SCOPUS:0037472356

VL - 337

SP - 13

EP - 16

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -