Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan

N. Chiba, Miyuki Morozumi, K. Sunaoshi, S. Takahashi, M. Takano, T. Komori, K. Sunakawa, K. Ubukata

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent pneumococcal conjugate vaccine (PCV7) is unavailable. We determined serotypes, genotypes indicating -lactam resistance, and antibiotic susceptibilities of 496 isolates from normally sterile sites in patients (193 children, 303 adults) from 186 institutions between August 2006 and July 2007. Disease presentations included sepsis (462%), pneumonia (315%), and meningitis (175%). Mortality was 14% in children and 221% in adults, many of whom had underlying diseases. In children, serotype 6B (225%) was followed by 19F (141%), and 14 (131%); potential coverages of PCV7 and PCV13 were 754% and 937%, respectively. In adults, serotype 12F (143%) was followed by 3 (113%), and 6B (103%); 23-valent polysaccharide vaccine (PPV23) coverage was 854%. Most serotype 12F strains were gPISP, with pbp2b gene alteration; carbapenem had an excellent MIC90. PCV7 is recommended for children and PPV23 for adults to increase prevention against IPD.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalEpidemiology and Infection
Volume138
Issue number1
DOIs
Publication statusPublished - 2010 Jan
Externally publishedYes

Fingerprint

Microbial Drug Resistance
Japan
Lactams
Carbapenems
Meningitis
Polysaccharides
Sepsis
Pneumonia
Genotype
Mortality
Serogroup
Genes

Keywords

  • Antibiotic resistance
  • Molecular epidemiology
  • Streptococcus pneumoniae (pneumococcus)
  • Surveillance
  • Vaccines

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

Cite this

Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan. / Chiba, N.; Morozumi, Miyuki; Sunaoshi, K.; Takahashi, S.; Takano, M.; Komori, T.; Sunakawa, K.; Ubukata, K.

In: Epidemiology and Infection, Vol. 138, No. 1, 01.2010, p. 61-68.

Research output: Contribution to journalArticle

Chiba, N, Morozumi, M, Sunaoshi, K, Takahashi, S, Takano, M, Komori, T, Sunakawa, K & Ubukata, K 2010, 'Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan', Epidemiology and Infection, vol. 138, no. 1, pp. 61-68. https://doi.org/10.1017/S0950268809990239
Chiba, N. ; Morozumi, Miyuki ; Sunaoshi, K. ; Takahashi, S. ; Takano, M. ; Komori, T. ; Sunakawa, K. ; Ubukata, K. / Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan. In: Epidemiology and Infection. 2010 ; Vol. 138, No. 1. pp. 61-68.
@article{8b877d88d3be457ab3a9f126d4d7ce4b,
title = "Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan",
abstract = "Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent pneumococcal conjugate vaccine (PCV7) is unavailable. We determined serotypes, genotypes indicating -lactam resistance, and antibiotic susceptibilities of 496 isolates from normally sterile sites in patients (193 children, 303 adults) from 186 institutions between August 2006 and July 2007. Disease presentations included sepsis (462{\%}), pneumonia (315{\%}), and meningitis (175{\%}). Mortality was 14{\%} in children and 221{\%} in adults, many of whom had underlying diseases. In children, serotype 6B (225{\%}) was followed by 19F (141{\%}), and 14 (131{\%}); potential coverages of PCV7 and PCV13 were 754{\%} and 937{\%}, respectively. In adults, serotype 12F (143{\%}) was followed by 3 (113{\%}), and 6B (103{\%}); 23-valent polysaccharide vaccine (PPV23) coverage was 854{\%}. Most serotype 12F strains were gPISP, with pbp2b gene alteration; carbapenem had an excellent MIC90. PCV7 is recommended for children and PPV23 for adults to increase prevention against IPD.",
keywords = "Antibiotic resistance, Molecular epidemiology, Streptococcus pneumoniae (pneumococcus), Surveillance, Vaccines",
author = "N. Chiba and Miyuki Morozumi and K. Sunaoshi and S. Takahashi and M. Takano and T. Komori and K. Sunakawa and K. Ubukata",
year = "2010",
month = "1",
doi = "10.1017/S0950268809990239",
language = "English",
volume = "138",
pages = "61--68",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "1",

}

TY - JOUR

T1 - Serotype and antibiotic resistance of isolates from patients with invasive pneumococcal disease in Japan

AU - Chiba, N.

AU - Morozumi, Miyuki

AU - Sunaoshi, K.

AU - Takahashi, S.

AU - Takano, M.

AU - Komori, T.

AU - Sunakawa, K.

AU - Ubukata, K.

PY - 2010/1

Y1 - 2010/1

N2 - Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent pneumococcal conjugate vaccine (PCV7) is unavailable. We determined serotypes, genotypes indicating -lactam resistance, and antibiotic susceptibilities of 496 isolates from normally sterile sites in patients (193 children, 303 adults) from 186 institutions between August 2006 and July 2007. Disease presentations included sepsis (462%), pneumonia (315%), and meningitis (175%). Mortality was 14% in children and 221% in adults, many of whom had underlying diseases. In children, serotype 6B (225%) was followed by 19F (141%), and 14 (131%); potential coverages of PCV7 and PCV13 were 754% and 937%, respectively. In adults, serotype 12F (143%) was followed by 3 (113%), and 6B (103%); 23-valent polysaccharide vaccine (PPV23) coverage was 854%. Most serotype 12F strains were gPISP, with pbp2b gene alteration; carbapenem had an excellent MIC90. PCV7 is recommended for children and PPV23 for adults to increase prevention against IPD.

AB - Invasive pneumococcal disease (IPD) is of concern in Japan, where the heptavalent pneumococcal conjugate vaccine (PCV7) is unavailable. We determined serotypes, genotypes indicating -lactam resistance, and antibiotic susceptibilities of 496 isolates from normally sterile sites in patients (193 children, 303 adults) from 186 institutions between August 2006 and July 2007. Disease presentations included sepsis (462%), pneumonia (315%), and meningitis (175%). Mortality was 14% in children and 221% in adults, many of whom had underlying diseases. In children, serotype 6B (225%) was followed by 19F (141%), and 14 (131%); potential coverages of PCV7 and PCV13 were 754% and 937%, respectively. In adults, serotype 12F (143%) was followed by 3 (113%), and 6B (103%); 23-valent polysaccharide vaccine (PPV23) coverage was 854%. Most serotype 12F strains were gPISP, with pbp2b gene alteration; carbapenem had an excellent MIC90. PCV7 is recommended for children and PPV23 for adults to increase prevention against IPD.

KW - Antibiotic resistance

KW - Molecular epidemiology

KW - Streptococcus pneumoniae (pneumococcus)

KW - Surveillance

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=73349139522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349139522&partnerID=8YFLogxK

U2 - 10.1017/S0950268809990239

DO - 10.1017/S0950268809990239

M3 - Article

VL - 138

SP - 61

EP - 68

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 1

ER -