Serous cystic neoplasm in an intrapancreatic accessory spleen

Shutaro Hori, Satoshi Nara, Kazuaki Shimada, Hidenori Ojima, Yae Kanai, Nobuyoshi Hiraoka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Serous cystic neoplasm (SCN) of the pancreas is a benign epithelial neoplasm, except in extremely rare malignant cases. Development of SCN in tissues other than the pancreas has been never reported. Here we present the first reported case of SCN in an intrapancreatic accessory spleen (IPAS). A 54-year-old female patient with von Hippel-Lindau (VHL) syndrome was found to have pancreatic tail mass. Pathologically the 25-mm solid mass was an IPAS showing proliferation of clear cuboidal tumor cells without atypia, forming numerous small cysts. The tumor cells were rich in cytoplasmic glycogen and distributed in the splenic tissue almost diffusely. Immunohistochemically, tumor cells were positive for cytokeratins, MUC6, and neuron-specific enolase, and negative for neuroendocrine markers. From these findings, we diagnosed the lesion as SCN in IPAS. This tumor is suggested to develop as a VHL-associated SCN from coexisting pancreatic tissue in IPAS rather than as a metastatic tumor.

Original languageEnglish
Pages (from-to)681-684
Number of pages4
JournalPathology international
Volume60
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1
Externally publishedYes

Keywords

  • accessory spleen
  • pancreas
  • serous cystic neoplasm
  • von Hippel-Lindau syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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