Serum acid-labile subunit is a good parameter for diagnosis of GH deficiency

M. Yamada, K. Fujii, T. Hasegawa, Y. Hasegawa

Research output: Contribution to journalArticle

Abstract

Acid-labile subunit (ALS) is one of the components of a ternary complex with insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) in the circulation. The role of ALS in the circulation is not well known, but the levels of ALS are dependent on GH levels, suggesting that ALS plays an important biological role in the circulation. This study is to research whether serum ALS levels are suitable parameters for the diagnosis of GH deficiency (GHD). In this study, ALS levels were measured by Western immunoblotting in sera from patients with GHD and hypophysectomised (hyper) rats. ALS levels of the patients with GHD were less than 10% of ALS levels of control age-matched children and adults. ALS levels of hyper rats were less than 10% of ALS levels of control (non-hyper) rats. The levels were partially reverted towards normal levels after rat GH treatment. Our data suggest that ALS levels are one of the best parameters for the diagnosis of GHD.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
Journalclinical pediatric endocrinology
Volume6
Issue numberSUPPL. 9
Publication statusPublished - 1997 Dec 1

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Keywords

  • Acid-labile subunit
  • GH deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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