Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study

Satomi Maeda, Yasushi Takeya, Ryosuke Oguro, Hiroshi Akasaka, Hirochika Ryuno, Mai Kabayama, Serina Yokoyama, Motonori Nagasawa, Taku Fujimoto, Masao Takeda, Miyuki Onishi-Takeya, Norihisa Itoh, Yoichi Takami, Koichi Yamamoto, Ken Sugimoto, Hiroki Inagaki, Madoka Ogawa, Takeshi Nakagawa, Saori Yasumoto, Yukie MasuiYasumichi Arai, Tatsuro Ishizaki, Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Hiromi Rakugi

Research output: Contribution to journalArticle

Abstract

Aim: The objective of this study was to clarify the relationship between cognitive function and the serum albumin/globulin ratio (A/G ratio) in community-dwelling Japanese older adults. Methods: Randomly extracted residents in both urban and rural parts of Japan were enrolled in this study. A total of 1827 participants with a mean age of 70 or 80 years were recruited. A venue survey method was carried out with comprehensive studies, including interviews, blood collection, physical examination and cognitive function tests. Results: Univariate analysis showed a significant positive correlation between the total Japanese version of the Montreal Cognitive Assessment score and the serum A/G ratio at the age of 70 and 80 years, in which better cognitive function was associated with a high serum A/G ratio. Multiple regression analysis with the total Japanese version of the Montreal Cognitive Assessment score as the dependent variable showed that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and sex were related to the Japanese version of the Montreal Cognitive Assessment total score at the age of 70 years, and that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and stroke were related at the age of 80 years. The serum A/G ratio showed a better correlation than the serum globulin levels at the age of 70 and 80 years (70 years: β = 0.131 vs –0.111, 80 years: β = 0.108 vs –0.071). Conclusions: We found a correlation between cognitive function and the serum A/G ratio in community-dwelling older people, suggesting that nutritional status and chronic inflammation might influence cognitive function. Geriatr Gerontol Int 2019; 19: 967–971.

Original languageEnglish
Pages (from-to)967-971
Number of pages5
JournalGeriatrics and Gerontology International
Volume19
Issue number10
DOIs
Publication statusPublished - 2019 Oct 1

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Independent Living
Serum Globulins
Serum Albumin
Cognition
community
stroke
C-Reactive Protein
education
regression analysis
Japan
resident
examination
Sex Education
interview
Nutritional Status
Physical Examination
Stroke
Regression Analysis
Interviews
Inflammation

Keywords

  • cognitive function
  • cross-sectional study
  • elderly
  • Japanese
  • serum albumin/globulin ratio

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people : The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. / Maeda, Satomi; Takeya, Yasushi; Oguro, Ryosuke; Akasaka, Hiroshi; Ryuno, Hirochika; Kabayama, Mai; Yokoyama, Serina; Nagasawa, Motonori; Fujimoto, Taku; Takeda, Masao; Onishi-Takeya, Miyuki; Itoh, Norihisa; Takami, Yoichi; Yamamoto, Koichi; Sugimoto, Ken; Inagaki, Hiroki; Ogawa, Madoka; Nakagawa, Takeshi; Yasumoto, Saori; Masui, Yukie; Arai, Yasumichi; Ishizaki, Tatsuro; Ikebe, Kazunori; Gondo, Yasuyuki; Kamide, Kei; Rakugi, Hiromi.

In: Geriatrics and Gerontology International, Vol. 19, No. 10, 01.10.2019, p. 967-971.

Research output: Contribution to journalArticle

Maeda, S, Takeya, Y, Oguro, R, Akasaka, H, Ryuno, H, Kabayama, M, Yokoyama, S, Nagasawa, M, Fujimoto, T, Takeda, M, Onishi-Takeya, M, Itoh, N, Takami, Y, Yamamoto, K, Sugimoto, K, Inagaki, H, Ogawa, M, Nakagawa, T, Yasumoto, S, Masui, Y, Arai, Y, Ishizaki, T, Ikebe, K, Gondo, Y, Kamide, K & Rakugi, H 2019, 'Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study', Geriatrics and Gerontology International, vol. 19, no. 10, pp. 967-971. https://doi.org/10.1111/ggi.13751
Maeda, Satomi ; Takeya, Yasushi ; Oguro, Ryosuke ; Akasaka, Hiroshi ; Ryuno, Hirochika ; Kabayama, Mai ; Yokoyama, Serina ; Nagasawa, Motonori ; Fujimoto, Taku ; Takeda, Masao ; Onishi-Takeya, Miyuki ; Itoh, Norihisa ; Takami, Yoichi ; Yamamoto, Koichi ; Sugimoto, Ken ; Inagaki, Hiroki ; Ogawa, Madoka ; Nakagawa, Takeshi ; Yasumoto, Saori ; Masui, Yukie ; Arai, Yasumichi ; Ishizaki, Tatsuro ; Ikebe, Kazunori ; Gondo, Yasuyuki ; Kamide, Kei ; Rakugi, Hiromi. / Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people : The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. In: Geriatrics and Gerontology International. 2019 ; Vol. 19, No. 10. pp. 967-971.
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AU - Maeda, Satomi

AU - Takeya, Yasushi

AU - Oguro, Ryosuke

AU - Akasaka, Hiroshi

AU - Ryuno, Hirochika

AU - Kabayama, Mai

AU - Yokoyama, Serina

AU - Nagasawa, Motonori

AU - Fujimoto, Taku

AU - Takeda, Masao

AU - Onishi-Takeya, Miyuki

AU - Itoh, Norihisa

AU - Takami, Yoichi

AU - Yamamoto, Koichi

AU - Sugimoto, Ken

AU - Inagaki, Hiroki

AU - Ogawa, Madoka

AU - Nakagawa, Takeshi

AU - Yasumoto, Saori

AU - Masui, Yukie

AU - Arai, Yasumichi

AU - Ishizaki, Tatsuro

AU - Ikebe, Kazunori

AU - Gondo, Yasuyuki

AU - Kamide, Kei

AU - Rakugi, Hiromi

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