Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery

Hiroshi Nakatani, Kazunori Kasama, Takashi Oshiro, Mitsuhiro Watanabe, Hiroshi Hirose, Hiroshi Itoh

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Bariatric surgery has been shown to improve glucose tolerance, although the mechanism has not been fully elucidated. Animal studies have suggested important roles of bile acid (BA) as a regulator of energy homeostasis and glucose metabolism. However, little is known about its role in humans. We investigated the longitudinal changes of BA, incretins, and adipokines after significant weight reduction in 34 Japanese adults with morbid obesity who underwent laparoscopic bariatric surgery. In subjects who underwent malabsorptive or restrictive surgery, body mass index had markedly decreased from 43.0 ± 6.5 (SD) to 37.8 ± 5.7 kg/m2 and from 45.3 ± 11.2 to 41.5 ± 10.5 kg/m2, respectively, at 1 month after surgery. Glycated hemoglobin decreased from 6.1% ± 1.5% to 5.2% ± 0.4% and from 6.2% ± 1.3% to 5.4% ± 0.7%, and total BA level increased from 3.1 ± 3.5 to 7.2 ± 5.3 μmol/L and from 3.2 ± 2.6 to 9.4 ± 10.0 μmol/L, respectively. At baseline, serum concentration of primary BA was positively correlated with plasma gastric inhibitory polypeptide level (r = 0.548, P = .001); and change in primary BA level was positively correlated with changes in plasma gastric inhibitory polypeptide (r = 0.626, P = .001) and serum immunoreactive insulin level (r = 0.592, P = .002) at 1 month after surgery. Furthermore, plasma glucagon-like peptide-1 and serum high-molecular weight adiponectin levels increased in both surgeries. These hormonal changes might explain the mechanism(s) of improved glucose tolerance after bariatric surgery in morbidly obese subjects.

Original languageEnglish
Pages (from-to)1400-1407
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume58
Issue number10
DOIs
Publication statusPublished - 2009 Oct

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Incretins
Bariatric Surgery
Adiponectin
Bile Acids and Salts
Molecular Weight
Gastric Inhibitory Polypeptide
Serum
Glucose
Adipokines
Glucagon-Like Peptide 1
Morbid Obesity
Glycosylated Hemoglobin A
Laparoscopy
Weight Loss
Body Mass Index
Homeostasis
Insulin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. / Nakatani, Hiroshi; Kasama, Kazunori; Oshiro, Takashi; Watanabe, Mitsuhiro; Hirose, Hiroshi; Itoh, Hiroshi.

In: Metabolism: Clinical and Experimental, Vol. 58, No. 10, 10.2009, p. 1400-1407.

Research output: Contribution to journalArticle

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abstract = "Bariatric surgery has been shown to improve glucose tolerance, although the mechanism has not been fully elucidated. Animal studies have suggested important roles of bile acid (BA) as a regulator of energy homeostasis and glucose metabolism. However, little is known about its role in humans. We investigated the longitudinal changes of BA, incretins, and adipokines after significant weight reduction in 34 Japanese adults with morbid obesity who underwent laparoscopic bariatric surgery. In subjects who underwent malabsorptive or restrictive surgery, body mass index had markedly decreased from 43.0 ± 6.5 (SD) to 37.8 ± 5.7 kg/m2 and from 45.3 ± 11.2 to 41.5 ± 10.5 kg/m2, respectively, at 1 month after surgery. Glycated hemoglobin decreased from 6.1{\%} ± 1.5{\%} to 5.2{\%} ± 0.4{\%} and from 6.2{\%} ± 1.3{\%} to 5.4{\%} ± 0.7{\%}, and total BA level increased from 3.1 ± 3.5 to 7.2 ± 5.3 μmol/L and from 3.2 ± 2.6 to 9.4 ± 10.0 μmol/L, respectively. At baseline, serum concentration of primary BA was positively correlated with plasma gastric inhibitory polypeptide level (r = 0.548, P = .001); and change in primary BA level was positively correlated with changes in plasma gastric inhibitory polypeptide (r = 0.626, P = .001) and serum immunoreactive insulin level (r = 0.592, P = .002) at 1 month after surgery. Furthermore, plasma glucagon-like peptide-1 and serum high-molecular weight adiponectin levels increased in both surgeries. These hormonal changes might explain the mechanism(s) of improved glucose tolerance after bariatric surgery in morbidly obese subjects.",
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