Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years

S. Matsunaga-Irie, H. Ueshima, W. R. Zaky, T. Kadowaki, R. W. Evans, Tomonori Okamura, T. Takamiya, Y. Kita, L. H. Kuller, Akira Sekikawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Ghrelin, a 28-amino-acid gastric peptide hormone, has an appetite-stimulating effect and controls the energy balance. Serum ghrelin levels inversely correlate with body mass index. Recently, several papers reported the ethnic difference in the ghrelin levels. To our knowledge, however, no studies have compared the serum ghrelin levels between Caucasians in the USA and the Japanese in Japan. Methods: We conducted a cross-sectional study of 189 men 40-49 years of age (91 US Caucasians in the U.S. and 98 Japanese in Japan) to examine serum ghrelin levels and metabolic and other factors. Results: Serum ghrelin levels correlated with waist circumferences and lipid profiles among Caucasian Americans and the Japanese. Serum ghrelin levels were significantly higher among Caucasian Americans than among the Japanese (904.5 (632.0, 1132.0) pg/mL, 508.0 (399.0, 1378.3) pg/mL (median and 95% confidence interval), respectively, P < 0.01), although Caucasian Americans were much more obese (BMI: 26.9 ± 3.3 kg/m2 versus 23.3 ± 3.1 kg/m2 respectively, P < 0.01). The ethnic difference remained after adjusting for metabolic factors, smoking status, and other factors (P < 0.01). Conclusions: We have shown in our population-based study that serum ghrelin levels among men aged 40-49 are significantly higher in Caucasian Americans than in the Japanese in Japan. Reasons for the ethnic difference in the ghrelin levels are largely unknown and warrant further investigation.

Original languageEnglish
Pages (from-to)591-593
Number of pages3
JournalDiabetes, Obesity and Metabolism
Volume9
Issue number4
DOIs
Publication statusPublished - 2007 Jul
Externally publishedYes

Fingerprint

Ghrelin
Serum
Japan
Peptide Hormones
Waist Circumference
Appetite
Stomach
Body Mass Index
Cross-Sectional Studies
Smoking
Confidence Intervals
Lipids
Amino Acids

Keywords

  • Caucasian
  • Ethinic difference
  • Ghrelin
  • Gut hormones
  • Japanese

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Matsunaga-Irie, S., Ueshima, H., Zaky, W. R., Kadowaki, T., Evans, R. W., Okamura, T., ... Sekikawa, A. (2007). Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years. Diabetes, Obesity and Metabolism, 9(4), 591-593. https://doi.org/10.1111/j.1463-1326.2006.00627.x

Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years. / Matsunaga-Irie, S.; Ueshima, H.; Zaky, W. R.; Kadowaki, T.; Evans, R. W.; Okamura, Tomonori; Takamiya, T.; Kita, Y.; Kuller, L. H.; Sekikawa, Akira.

In: Diabetes, Obesity and Metabolism, Vol. 9, No. 4, 07.2007, p. 591-593.

Research output: Contribution to journalArticle

Matsunaga-Irie, S, Ueshima, H, Zaky, WR, Kadowaki, T, Evans, RW, Okamura, T, Takamiya, T, Kita, Y, Kuller, LH & Sekikawa, A 2007, 'Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years', Diabetes, Obesity and Metabolism, vol. 9, no. 4, pp. 591-593. https://doi.org/10.1111/j.1463-1326.2006.00627.x
Matsunaga-Irie, S. ; Ueshima, H. ; Zaky, W. R. ; Kadowaki, T. ; Evans, R. W. ; Okamura, Tomonori ; Takamiya, T. ; Kita, Y. ; Kuller, L. H. ; Sekikawa, Akira. / Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40-49 years. In: Diabetes, Obesity and Metabolism. 2007 ; Vol. 9, No. 4. pp. 591-593.
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abstract = "Background: Ghrelin, a 28-amino-acid gastric peptide hormone, has an appetite-stimulating effect and controls the energy balance. Serum ghrelin levels inversely correlate with body mass index. Recently, several papers reported the ethnic difference in the ghrelin levels. To our knowledge, however, no studies have compared the serum ghrelin levels between Caucasians in the USA and the Japanese in Japan. Methods: We conducted a cross-sectional study of 189 men 40-49 years of age (91 US Caucasians in the U.S. and 98 Japanese in Japan) to examine serum ghrelin levels and metabolic and other factors. Results: Serum ghrelin levels correlated with waist circumferences and lipid profiles among Caucasian Americans and the Japanese. Serum ghrelin levels were significantly higher among Caucasian Americans than among the Japanese (904.5 (632.0, 1132.0) pg/mL, 508.0 (399.0, 1378.3) pg/mL (median and 95{\%} confidence interval), respectively, P < 0.01), although Caucasian Americans were much more obese (BMI: 26.9 ± 3.3 kg/m2 versus 23.3 ± 3.1 kg/m2 respectively, P < 0.01). The ethnic difference remained after adjusting for metabolic factors, smoking status, and other factors (P < 0.01). Conclusions: We have shown in our population-based study that serum ghrelin levels among men aged 40-49 are significantly higher in Caucasian Americans than in the Japanese in Japan. Reasons for the ethnic difference in the ghrelin levels are largely unknown and warrant further investigation.",
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AU - Ueshima, H.

AU - Zaky, W. R.

AU - Kadowaki, T.

AU - Evans, R. W.

AU - Okamura, Tomonori

AU - Takamiya, T.

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AU - Sekikawa, Akira

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