Serum immunoglobulin a concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage

Kengo Tomita, Toshiaki Teratani, Hirokazu Yokoyama, Takahiro Suzuki, Rie Irie, Hirotoshi Ebinuma, Hidetsugu Saito, Ryota Hokari, Soichiro Miura, Toshifumi Hibi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Aims The similarity of alcoholic liver disease and nonalcoholic steatohepatitis (NASH) in terms of pathogenic mechanisms suggests that immunoglobulin A (IgA) may play an important role in the pathogenesis of NASH. We aimed to determine whether serum IgA concentrations allow a diagnosis of liver fibrosis in NASH. Methods We compared serum IgA concentrations between 108 patients with stages 0-2 NASH and 19 patients with stage 3 NASH. Results In a univariate analysis, age (P<0.0001), gender (P = 0.0039), serum albumin level (P = 0.0192), AST (P<0.0001), AST/ALT ratio (P<0.0001), platelet count (P = 0.0027), hyaluronic acid level (P<0.0001), fasting blood sugar (FBS) (P = 0.0013), IRI (P = 0.0001), prothrombin time (%) (P = 0.0287), IgA (P<0.0001), total sum of IgG, IgA, and IgM (P = 0.0049), and IgA/ (IgG + IgA + IgM) (P = 0.0105) were significantly elevated in severe-stage NASH patients compared with the early-stage NASH group. Multiple logistic regression analysis showed that in severe-stage NASH patients, only serum IgA concentrations were significantly elevated (P = 0.0225) relative to early-stage NASH patients. The area under the curve (AUC) of serum IgA concentrations was 0.758 for detecting severe-stage NASH compared with early-stage NASH. Conclusions Serum IgA concentration could be a useful independent predictor for assessing the pre-cirrhotic progression of NASH.

Original languageEnglish
Pages (from-to)3648-3654
Number of pages7
JournalDigestive Diseases and Sciences
Volume56
Issue number12
DOIs
Publication statusPublished - 2011 Dec

Fingerprint

Liver Cirrhosis
Immunoglobulins
Immunoglobulin A
Serum
Immunoglobulin M
Non-alcoholic Fatty Liver Disease
Immunoglobulin G
Alcoholic Liver Diseases
Prothrombin Time
Hyaluronic Acid
Platelet Count
Serum Albumin
Area Under Curve
Blood Glucose
Fasting
Logistic Models
Regression Analysis

Keywords

  • Diagnosis
  • Immunoglobulin A
  • Liver fibrosis
  • Nonalcoholic steatohepatitis

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Serum immunoglobulin a concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage. / Tomita, Kengo; Teratani, Toshiaki; Yokoyama, Hirokazu; Suzuki, Takahiro; Irie, Rie; Ebinuma, Hirotoshi; Saito, Hidetsugu; Hokari, Ryota; Miura, Soichiro; Hibi, Toshifumi.

In: Digestive Diseases and Sciences, Vol. 56, No. 12, 12.2011, p. 3648-3654.

Research output: Contribution to journalArticle

Tomita, Kengo ; Teratani, Toshiaki ; Yokoyama, Hirokazu ; Suzuki, Takahiro ; Irie, Rie ; Ebinuma, Hirotoshi ; Saito, Hidetsugu ; Hokari, Ryota ; Miura, Soichiro ; Hibi, Toshifumi. / Serum immunoglobulin a concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage. In: Digestive Diseases and Sciences. 2011 ; Vol. 56, No. 12. pp. 3648-3654.
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abstract = "Background and Aims The similarity of alcoholic liver disease and nonalcoholic steatohepatitis (NASH) in terms of pathogenic mechanisms suggests that immunoglobulin A (IgA) may play an important role in the pathogenesis of NASH. We aimed to determine whether serum IgA concentrations allow a diagnosis of liver fibrosis in NASH. Methods We compared serum IgA concentrations between 108 patients with stages 0-2 NASH and 19 patients with stage 3 NASH. Results In a univariate analysis, age (P<0.0001), gender (P = 0.0039), serum albumin level (P = 0.0192), AST (P<0.0001), AST/ALT ratio (P<0.0001), platelet count (P = 0.0027), hyaluronic acid level (P<0.0001), fasting blood sugar (FBS) (P = 0.0013), IRI (P = 0.0001), prothrombin time ({\%}) (P = 0.0287), IgA (P<0.0001), total sum of IgG, IgA, and IgM (P = 0.0049), and IgA/ (IgG + IgA + IgM) (P = 0.0105) were significantly elevated in severe-stage NASH patients compared with the early-stage NASH group. Multiple logistic regression analysis showed that in severe-stage NASH patients, only serum IgA concentrations were significantly elevated (P = 0.0225) relative to early-stage NASH patients. The area under the curve (AUC) of serum IgA concentrations was 0.758 for detecting severe-stage NASH compared with early-stage NASH. Conclusions Serum IgA concentration could be a useful independent predictor for assessing the pre-cirrhotic progression of NASH.",
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T1 - Serum immunoglobulin a concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage

AU - Tomita, Kengo

AU - Teratani, Toshiaki

AU - Yokoyama, Hirokazu

AU - Suzuki, Takahiro

AU - Irie, Rie

AU - Ebinuma, Hirotoshi

AU - Saito, Hidetsugu

AU - Hokari, Ryota

AU - Miura, Soichiro

AU - Hibi, Toshifumi

PY - 2011/12

Y1 - 2011/12

N2 - Background and Aims The similarity of alcoholic liver disease and nonalcoholic steatohepatitis (NASH) in terms of pathogenic mechanisms suggests that immunoglobulin A (IgA) may play an important role in the pathogenesis of NASH. We aimed to determine whether serum IgA concentrations allow a diagnosis of liver fibrosis in NASH. Methods We compared serum IgA concentrations between 108 patients with stages 0-2 NASH and 19 patients with stage 3 NASH. Results In a univariate analysis, age (P<0.0001), gender (P = 0.0039), serum albumin level (P = 0.0192), AST (P<0.0001), AST/ALT ratio (P<0.0001), platelet count (P = 0.0027), hyaluronic acid level (P<0.0001), fasting blood sugar (FBS) (P = 0.0013), IRI (P = 0.0001), prothrombin time (%) (P = 0.0287), IgA (P<0.0001), total sum of IgG, IgA, and IgM (P = 0.0049), and IgA/ (IgG + IgA + IgM) (P = 0.0105) were significantly elevated in severe-stage NASH patients compared with the early-stage NASH group. Multiple logistic regression analysis showed that in severe-stage NASH patients, only serum IgA concentrations were significantly elevated (P = 0.0225) relative to early-stage NASH patients. The area under the curve (AUC) of serum IgA concentrations was 0.758 for detecting severe-stage NASH compared with early-stage NASH. Conclusions Serum IgA concentration could be a useful independent predictor for assessing the pre-cirrhotic progression of NASH.

AB - Background and Aims The similarity of alcoholic liver disease and nonalcoholic steatohepatitis (NASH) in terms of pathogenic mechanisms suggests that immunoglobulin A (IgA) may play an important role in the pathogenesis of NASH. We aimed to determine whether serum IgA concentrations allow a diagnosis of liver fibrosis in NASH. Methods We compared serum IgA concentrations between 108 patients with stages 0-2 NASH and 19 patients with stage 3 NASH. Results In a univariate analysis, age (P<0.0001), gender (P = 0.0039), serum albumin level (P = 0.0192), AST (P<0.0001), AST/ALT ratio (P<0.0001), platelet count (P = 0.0027), hyaluronic acid level (P<0.0001), fasting blood sugar (FBS) (P = 0.0013), IRI (P = 0.0001), prothrombin time (%) (P = 0.0287), IgA (P<0.0001), total sum of IgG, IgA, and IgM (P = 0.0049), and IgA/ (IgG + IgA + IgM) (P = 0.0105) were significantly elevated in severe-stage NASH patients compared with the early-stage NASH group. Multiple logistic regression analysis showed that in severe-stage NASH patients, only serum IgA concentrations were significantly elevated (P = 0.0225) relative to early-stage NASH patients. The area under the curve (AUC) of serum IgA concentrations was 0.758 for detecting severe-stage NASH compared with early-stage NASH. Conclusions Serum IgA concentration could be a useful independent predictor for assessing the pre-cirrhotic progression of NASH.

KW - Diagnosis

KW - Immunoglobulin A

KW - Liver fibrosis

KW - Nonalcoholic steatohepatitis

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