Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation

Takehiro Kimura, Seiji Takatsuki, Kohei Inagawa, Yoshinori Katsumata, Takahiko Nishiyama, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoshiyasu Aizawa, Yoko Tanimoto, Kojiro Tanimoto, Keiichi Fukuda

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: We investigated various serum inflammatory markers to predict ablation responders who have no atrial fibrillation (AF) relapse after the initial ablation. Methods: Forty-four consecutive AF patients (age: 59 ± 8 years, paroxysmal: 31, CHADS2: 1.1 ± 1.1) who underwent an initial pulmonary vein isolation were investigated. Various serum inflammatory markers, such as adiponectin, ANP, BNP, 1CTP, F1+2, hs-CRP, IL-6, intact P1NP, MDA-LDL, MMP-2, TGF-β, TIMP-2, and TNF-α, were evaluated prior to ablation. AF relapse was defined as AF documented in telemonitoring electrocardiograms twice a day during 9.7 ± 2.4 months of follow-up with three months of a blanking-period. Results: A total of 29 patients (paroxysmal: 21) maintained sinus rhythm after the initial catheter ablation. These ablation responders had significantly lower MMP-2 (Sinus vs. Relapsed: 748 ± 132.7 vs. 841.2 ± 152.4 ng/mL, P=0.042) and TNF-α (1.1 ± 0.4 vs. 1.8 ± 1.7 pg/mL, P=0.046) levels prior to ablation. A BNP-adjusted Cox multivariate regression analysis revealed that the independent predictive factor for AF recurrence was high MMP-2 levels (>766 ng/mL) accompanied by high TNF-α levels (>1.2 pg/mL). Conclusions: The levels of MMP-2 and TNF-α might be useful for predicting initial AF catheter ablation responders.

Original languageEnglish
Pages (from-to)636-643
Number of pages8
JournalHeart Lung and Circulation
Volume23
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Catheter Ablation
Atrial Fibrillation
Biomarkers
Inflammation
Matrix Metalloproteinases
Recurrence
Tissue Inhibitor of Metalloproteinase-2
Pulmonary Veins
Adiponectin
Atrial Natriuretic Factor
LDL Lipoproteins
Interleukin-6
Electrocardiography
Multivariate Analysis
Regression Analysis

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Follow-up, inflammation
  • Matrix metalloproteinase-2
  • Tumour necrosis factor-α

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation. / Kimura, Takehiro; Takatsuki, Seiji; Inagawa, Kohei; Katsumata, Yoshinori; Nishiyama, Takahiko; Nishiyama, Nobuhiro; Fukumoto, Kotaro; Aizawa, Yoshiyasu; Tanimoto, Yoko; Tanimoto, Kojiro; Fukuda, Keiichi.

In: Heart Lung and Circulation, Vol. 23, No. 7, 2014, p. 636-643.

Research output: Contribution to journalArticle

Kimura, T, Takatsuki, S, Inagawa, K, Katsumata, Y, Nishiyama, T, Nishiyama, N, Fukumoto, K, Aizawa, Y, Tanimoto, Y, Tanimoto, K & Fukuda, K 2014, 'Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation', Heart Lung and Circulation, vol. 23, no. 7, pp. 636-643. https://doi.org/10.1016/j.hlc.2014.02.003
Kimura, Takehiro ; Takatsuki, Seiji ; Inagawa, Kohei ; Katsumata, Yoshinori ; Nishiyama, Takahiko ; Nishiyama, Nobuhiro ; Fukumoto, Kotaro ; Aizawa, Yoshiyasu ; Tanimoto, Yoko ; Tanimoto, Kojiro ; Fukuda, Keiichi. / Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation. In: Heart Lung and Circulation. 2014 ; Vol. 23, No. 7. pp. 636-643.
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abstract = "Background: We investigated various serum inflammatory markers to predict ablation responders who have no atrial fibrillation (AF) relapse after the initial ablation. Methods: Forty-four consecutive AF patients (age: 59 ± 8 years, paroxysmal: 31, CHADS2: 1.1 ± 1.1) who underwent an initial pulmonary vein isolation were investigated. Various serum inflammatory markers, such as adiponectin, ANP, BNP, 1CTP, F1+2, hs-CRP, IL-6, intact P1NP, MDA-LDL, MMP-2, TGF-β, TIMP-2, and TNF-α, were evaluated prior to ablation. AF relapse was defined as AF documented in telemonitoring electrocardiograms twice a day during 9.7 ± 2.4 months of follow-up with three months of a blanking-period. Results: A total of 29 patients (paroxysmal: 21) maintained sinus rhythm after the initial catheter ablation. These ablation responders had significantly lower MMP-2 (Sinus vs. Relapsed: 748 ± 132.7 vs. 841.2 ± 152.4 ng/mL, P=0.042) and TNF-α (1.1 ± 0.4 vs. 1.8 ± 1.7 pg/mL, P=0.046) levels prior to ablation. A BNP-adjusted Cox multivariate regression analysis revealed that the independent predictive factor for AF recurrence was high MMP-2 levels (>766 ng/mL) accompanied by high TNF-α levels (>1.2 pg/mL). Conclusions: The levels of MMP-2 and TNF-α might be useful for predicting initial AF catheter ablation responders.",
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T1 - Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation

AU - Kimura, Takehiro

AU - Takatsuki, Seiji

AU - Inagawa, Kohei

AU - Katsumata, Yoshinori

AU - Nishiyama, Takahiko

AU - Nishiyama, Nobuhiro

AU - Fukumoto, Kotaro

AU - Aizawa, Yoshiyasu

AU - Tanimoto, Yoko

AU - Tanimoto, Kojiro

AU - Fukuda, Keiichi

PY - 2014

Y1 - 2014

N2 - Background: We investigated various serum inflammatory markers to predict ablation responders who have no atrial fibrillation (AF) relapse after the initial ablation. Methods: Forty-four consecutive AF patients (age: 59 ± 8 years, paroxysmal: 31, CHADS2: 1.1 ± 1.1) who underwent an initial pulmonary vein isolation were investigated. Various serum inflammatory markers, such as adiponectin, ANP, BNP, 1CTP, F1+2, hs-CRP, IL-6, intact P1NP, MDA-LDL, MMP-2, TGF-β, TIMP-2, and TNF-α, were evaluated prior to ablation. AF relapse was defined as AF documented in telemonitoring electrocardiograms twice a day during 9.7 ± 2.4 months of follow-up with three months of a blanking-period. Results: A total of 29 patients (paroxysmal: 21) maintained sinus rhythm after the initial catheter ablation. These ablation responders had significantly lower MMP-2 (Sinus vs. Relapsed: 748 ± 132.7 vs. 841.2 ± 152.4 ng/mL, P=0.042) and TNF-α (1.1 ± 0.4 vs. 1.8 ± 1.7 pg/mL, P=0.046) levels prior to ablation. A BNP-adjusted Cox multivariate regression analysis revealed that the independent predictive factor for AF recurrence was high MMP-2 levels (>766 ng/mL) accompanied by high TNF-α levels (>1.2 pg/mL). Conclusions: The levels of MMP-2 and TNF-α might be useful for predicting initial AF catheter ablation responders.

AB - Background: We investigated various serum inflammatory markers to predict ablation responders who have no atrial fibrillation (AF) relapse after the initial ablation. Methods: Forty-four consecutive AF patients (age: 59 ± 8 years, paroxysmal: 31, CHADS2: 1.1 ± 1.1) who underwent an initial pulmonary vein isolation were investigated. Various serum inflammatory markers, such as adiponectin, ANP, BNP, 1CTP, F1+2, hs-CRP, IL-6, intact P1NP, MDA-LDL, MMP-2, TGF-β, TIMP-2, and TNF-α, were evaluated prior to ablation. AF relapse was defined as AF documented in telemonitoring electrocardiograms twice a day during 9.7 ± 2.4 months of follow-up with three months of a blanking-period. Results: A total of 29 patients (paroxysmal: 21) maintained sinus rhythm after the initial catheter ablation. These ablation responders had significantly lower MMP-2 (Sinus vs. Relapsed: 748 ± 132.7 vs. 841.2 ± 152.4 ng/mL, P=0.042) and TNF-α (1.1 ± 0.4 vs. 1.8 ± 1.7 pg/mL, P=0.046) levels prior to ablation. A BNP-adjusted Cox multivariate regression analysis revealed that the independent predictive factor for AF recurrence was high MMP-2 levels (>766 ng/mL) accompanied by high TNF-α levels (>1.2 pg/mL). Conclusions: The levels of MMP-2 and TNF-α might be useful for predicting initial AF catheter ablation responders.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Follow-up, inflammation

KW - Matrix metalloproteinase-2

KW - Tumour necrosis factor-α

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