Serum leptin concentrations in patients with thyroid disorders

Tadashi Yoshida, Naoko Momotani, Matsuhiko Hayashi, Toshiaki Monkawa, Kunihiko Ito, Takao Saruta

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

OBJECTIVE. Leptin, the obese gene product, is secreted exclusively by adipocytes and is thought to act as a lipostatic signal that regulates body weight homeostasis. We previously reported that thyroid hormone is one of the up-regulating factors of leptin in vitro. T3, at physiological concentrations, stimulates leptin mRNA expression and leptin secretion by 3T3-L1 adipocytes. The aim of this study was to explore the role of thyroid hormone in the regulation of leptin in humans. DESIGN AND PATIENTS. A total of 59 non-obese women aged 38·4 + 1·8 years (mean · SEM) were studied: 19 patients with hyperthyroidism, 17 patients with hypothyroidism, and 23 normal control subjects. The correlation between serum leptin concentrations and body mass index (BMI) was analyzed, and serum leptin levels were compared among the three groups. MEASUREMENTS. Serum leptin concentrations were measured by radioimmunoassay. RESULTS. Serum leptin concentrations after logarithmic transformation were correlated significantly (P<0·05) with BMI in the hyperthyroid (r -0·46), the hypothyroid (r=0·84), and normal (r- 0·63) groups. Even though age, body weight, and BMI were similar in all groups, serum leptin levels in the hypothyroid patients (5·30 + 1·12 μg/l) were significantly (P<0·05) lower than in the hyperthyroid and normal groups (6·87 + 0·66 and 6·58 ± 0·68 μg/l, respectively). CONCLUSIONS. These results indicate that thyroid hormone may play an important role in the appropriate secretion of leptin in humans.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalClinical Endocrinology
Volume48
Issue number3
DOIs
Publication statusPublished - 1998

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Leptin
Thyroid Gland
Serum
Hyperthyroidism
Thyroid Hormones
Body Mass Index
Adipocytes
Body Weight
Hypothyroidism
Radioimmunoassay
Homeostasis
Messenger RNA

ASJC Scopus subject areas

  • Endocrinology

Cite this

Serum leptin concentrations in patients with thyroid disorders. / Yoshida, Tadashi; Momotani, Naoko; Hayashi, Matsuhiko; Monkawa, Toshiaki; Ito, Kunihiko; Saruta, Takao.

In: Clinical Endocrinology, Vol. 48, No. 3, 1998, p. 299-302.

Research output: Contribution to journalArticle

Yoshida, Tadashi ; Momotani, Naoko ; Hayashi, Matsuhiko ; Monkawa, Toshiaki ; Ito, Kunihiko ; Saruta, Takao. / Serum leptin concentrations in patients with thyroid disorders. In: Clinical Endocrinology. 1998 ; Vol. 48, No. 3. pp. 299-302.
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