Serum leptin level: Possible association with haematopoiesis in adolescents, independent of body mass index and serum insulin

Hiroshi Hirose, Ikuo Saito, Toshihide Kawai, Keiko Nakamura, Hiroshi Maruyama, Takao Saruta

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

1. The obese gene product leptin, secreted exclusively from adipocytes, was discovered to serve as a satiety factor and to play an important role in regulating body weight. In adults, the serum leptin level reportedly increases with the degree of obesity. Leptin receptors are expressed in various tissues, and recent in vitro studies suggest a role for leptin in haematopoiesis. 2. The present study was designed to clarify the relationship between serum leptin and body mass index, peripheral blood cell counts, serum cholesterol, high-density lipoprotein-cholesterol, insulin and cortisol levels in 299 Japanese male adolescents aged 15-16 years. 3. With simple linear correlation, log [serum leptin] showed a strong correlation with body mass index (r = 0.56), log [insulin] (r = 0.36) and leucocyte count (r = 0.22) (P < 0.001 for all). There were also correlations with systolic blood pressure, erythrocyte count, haematocrit and high-density lipoprotein-cholesterol (P < 0.01 for all). Even after adjustment for body mass index and log [insulin], log [leptin] correlated with leucocyte (P = 0.004) and erythrocyte (P = 0.057) counts. Stepwise multiple regression analyses revealed log [leptin] to correlate significantly with body mass index, log [insulin] and the leucocyte count (P < 0.005 for all, r2 = 0.399). 4. To our knowledge, this is the first clinical study to show the possible association of serum leptin level with blood cell counts, independent of body mass index and serum insulin. We conclude that these data further support a role for leptin in haematopoiesis.

Original languageEnglish
Pages (from-to)633-636
Number of pages4
JournalClinical Science
Volume94
Issue number6
Publication statusPublished - 1998

Fingerprint

Hematopoiesis
Leptin
Body Mass Index
Insulin
Serum
Blood Cell Count
Leukocyte Count
HDL Cholesterol
Blood Pressure
Leptin Receptors
Erythrocyte Count
Hematocrit
Adipocytes
Hydrocortisone
Leukocytes
Obesity
Erythrocytes
Cholesterol
Body Weight
Regression Analysis

Keywords

  • Adolescent
  • Body mass index
  • Haematopoiesis
  • Insulin
  • Leptin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Serum leptin level : Possible association with haematopoiesis in adolescents, independent of body mass index and serum insulin. / Hirose, Hiroshi; Saito, Ikuo; Kawai, Toshihide; Nakamura, Keiko; Maruyama, Hiroshi; Saruta, Takao.

In: Clinical Science, Vol. 94, No. 6, 1998, p. 633-636.

Research output: Contribution to journalArticle

Hirose, Hiroshi ; Saito, Ikuo ; Kawai, Toshihide ; Nakamura, Keiko ; Maruyama, Hiroshi ; Saruta, Takao. / Serum leptin level : Possible association with haematopoiesis in adolescents, independent of body mass index and serum insulin. In: Clinical Science. 1998 ; Vol. 94, No. 6. pp. 633-636.
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