Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese

Tomonori Okamura, Katsuyuki Miura, Tatsuya Sawamura, Aya Kadota, Takashi Hisamatsu, Akira Fujiyoshi, Naomi Miyamatsu, Naoyuki Takashima, Naoko Miyagawa, Takashi Kadowaki, Takayoshi Ohkubo, Yoshitaka Murakami, Yasuyuki Nakamura, Hirotsugu Ueshima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations. Methods A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results Serum LAB levels (median [interquartile range], μg cs/L) were 5341 μg cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 μm) compared with the first quartile (797 μm) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC ≥ 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 μm (12.7), 856 μm (16.7) in the low LAB/hypercholesterolemia group, and 833 μm (8.4) in the low LAB/normal cholesterol group (P =.004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication. Conclusion Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia.

Original languageEnglish
Pages (from-to)172-180e1
JournalJournal of Clinical Lipidology
Volume10
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Independent Living
Carotid Intima-Media Thickness
Apolipoproteins B
Ligands
Serum
Hypercholesterolemia
Cholesterol
Lipids
Common Carotid Artery
Alcohol Drinking
C-Reactive Protein
HDL Cholesterol

Keywords

  • Carotid intima-media thickness
  • Hypercholesterolemia
  • Lectin-like oxidized LDL receptor 1
  • LOX-1 ligand containing ApoB
  • Population
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese. / Okamura, Tomonori; Miura, Katsuyuki; Sawamura, Tatsuya; Kadota, Aya; Hisamatsu, Takashi; Fujiyoshi, Akira; Miyamatsu, Naomi; Takashima, Naoyuki; Miyagawa, Naoko; Kadowaki, Takashi; Ohkubo, Takayoshi; Murakami, Yoshitaka; Nakamura, Yasuyuki; Ueshima, Hirotsugu.

In: Journal of Clinical Lipidology, Vol. 10, No. 1, 01.01.2016, p. 172-180e1.

Research output: Contribution to journalArticle

Okamura, T, Miura, K, Sawamura, T, Kadota, A, Hisamatsu, T, Fujiyoshi, A, Miyamatsu, N, Takashima, N, Miyagawa, N, Kadowaki, T, Ohkubo, T, Murakami, Y, Nakamura, Y & Ueshima, H 2016, 'Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese', Journal of Clinical Lipidology, vol. 10, no. 1, pp. 172-180e1. https://doi.org/10.1016/j.jacl.2015.10.010
Okamura, Tomonori ; Miura, Katsuyuki ; Sawamura, Tatsuya ; Kadota, Aya ; Hisamatsu, Takashi ; Fujiyoshi, Akira ; Miyamatsu, Naomi ; Takashima, Naoyuki ; Miyagawa, Naoko ; Kadowaki, Takashi ; Ohkubo, Takayoshi ; Murakami, Yoshitaka ; Nakamura, Yasuyuki ; Ueshima, Hirotsugu. / Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese. In: Journal of Clinical Lipidology. 2016 ; Vol. 10, No. 1. pp. 172-180e1.
@article{8c830003a1f74c4ea259be6ceced6b62,
title = "Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese",
abstract = "Background The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations. Methods A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results Serum LAB levels (median [interquartile range], μg cs/L) were 5341 μg cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 μm) compared with the first quartile (797 μm) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC ≥ 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 μm (12.7), 856 μm (16.7) in the low LAB/hypercholesterolemia group, and 833 μm (8.4) in the low LAB/normal cholesterol group (P =.004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication. Conclusion Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia.",
keywords = "Carotid intima-media thickness, Hypercholesterolemia, Lectin-like oxidized LDL receptor 1, LOX-1 ligand containing ApoB, Population, Risk factors",
author = "Tomonori Okamura and Katsuyuki Miura and Tatsuya Sawamura and Aya Kadota and Takashi Hisamatsu and Akira Fujiyoshi and Naomi Miyamatsu and Naoyuki Takashima and Naoko Miyagawa and Takashi Kadowaki and Takayoshi Ohkubo and Yoshitaka Murakami and Yasuyuki Nakamura and Hirotsugu Ueshima",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.jacl.2015.10.010",
language = "English",
volume = "10",
pages = "172--180e1",
journal = "Journal of Clinical Lipidology",
issn = "1933-2874",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese

AU - Okamura, Tomonori

AU - Miura, Katsuyuki

AU - Sawamura, Tatsuya

AU - Kadota, Aya

AU - Hisamatsu, Takashi

AU - Fujiyoshi, Akira

AU - Miyamatsu, Naomi

AU - Takashima, Naoyuki

AU - Miyagawa, Naoko

AU - Kadowaki, Takashi

AU - Ohkubo, Takayoshi

AU - Murakami, Yoshitaka

AU - Nakamura, Yasuyuki

AU - Ueshima, Hirotsugu

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations. Methods A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results Serum LAB levels (median [interquartile range], μg cs/L) were 5341 μg cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 μm) compared with the first quartile (797 μm) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC ≥ 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 μm (12.7), 856 μm (16.7) in the low LAB/hypercholesterolemia group, and 833 μm (8.4) in the low LAB/normal cholesterol group (P =.004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication. Conclusion Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia.

AB - Background The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations. Methods A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results Serum LAB levels (median [interquartile range], μg cs/L) were 5341 μg cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 μm) compared with the first quartile (797 μm) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC ≥ 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 μm (12.7), 856 μm (16.7) in the low LAB/hypercholesterolemia group, and 833 μm (8.4) in the low LAB/normal cholesterol group (P =.004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication. Conclusion Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia.

KW - Carotid intima-media thickness

KW - Hypercholesterolemia

KW - Lectin-like oxidized LDL receptor 1

KW - LOX-1 ligand containing ApoB

KW - Population

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84958837399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958837399&partnerID=8YFLogxK

U2 - 10.1016/j.jacl.2015.10.010

DO - 10.1016/j.jacl.2015.10.010

M3 - Article

C2 - 26892134

AN - SCOPUS:84958837399

VL - 10

SP - 172-180e1

JO - Journal of Clinical Lipidology

JF - Journal of Clinical Lipidology

SN - 1933-2874

IS - 1

ER -