Abstract
We have recently found that serum level of pigment epithelium derived factor (PEDF) is significantly increased in proportion to the accumulation of the number of the components of the metabolic syndrome. Although high heart rate is also associated with metabolic risk factors for atherosclerosis, the correlation between serum level of PEDF and resting heart rate remains to be elucidated. In this study, we examined their relationship in Japanese outpatients. Four hundred two consecutive outpatients at Nakamura Clinic (141 male and 261 female; mean age 74.9 ± 9.9) underwent a complete history and physical examination, determination of blood chemistries and PEDF levels. In multiple regression analysis, smoking (p = 0.003), use of β-blockers (p = 0.010, inversely), presence of atrial fibrillation (p = 0.014), PEDF (p = 0.018) and glucose levels (p = 0.033) were independently correlated to resting heart rate. Further, when mean serum PEDF levels were stratified by resting heart rates, a linear and significant trend (p = 0.025) was observed. The present study demonstrated for the first time that serum level of PEDF was one of the independent determinants of resting heart rate in Japanese outpatients. PEDF may play some role in sympathetic nerve activity.
| Original language | English |
|---|---|
| Pages (from-to) | 245-247 |
| Number of pages | 3 |
| Journal | International Journal of Cardiology |
| Volume | 136 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Aug 14 |
| Externally published | Yes |
Fingerprint
Keywords
- Cardiovascular disease
- PEDF
- Resting heart rate
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Serum level of pigment epithelium derived factor (PEDF) is an independent determinant of resting heart rate in Japanese subjects. / Nakamura, Kazuo; Yamagishi, Sho ichi; Adachi, Hisashi; Matsui, Takanori; Kurita, Yayoi; Inoue, Hiroyoshi.
In: International Journal of Cardiology, Vol. 136, No. 2, 14.08.2009, p. 245-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum level of pigment epithelium derived factor (PEDF) is an independent determinant of resting heart rate in Japanese subjects
AU - Nakamura, Kazuo
AU - Yamagishi, Sho ichi
AU - Adachi, Hisashi
AU - Matsui, Takanori
AU - Kurita, Yayoi
AU - Inoue, Hiroyoshi
PY - 2009/8/14
Y1 - 2009/8/14
N2 - We have recently found that serum level of pigment epithelium derived factor (PEDF) is significantly increased in proportion to the accumulation of the number of the components of the metabolic syndrome. Although high heart rate is also associated with metabolic risk factors for atherosclerosis, the correlation between serum level of PEDF and resting heart rate remains to be elucidated. In this study, we examined their relationship in Japanese outpatients. Four hundred two consecutive outpatients at Nakamura Clinic (141 male and 261 female; mean age 74.9 ± 9.9) underwent a complete history and physical examination, determination of blood chemistries and PEDF levels. In multiple regression analysis, smoking (p = 0.003), use of β-blockers (p = 0.010, inversely), presence of atrial fibrillation (p = 0.014), PEDF (p = 0.018) and glucose levels (p = 0.033) were independently correlated to resting heart rate. Further, when mean serum PEDF levels were stratified by resting heart rates, a linear and significant trend (p = 0.025) was observed. The present study demonstrated for the first time that serum level of PEDF was one of the independent determinants of resting heart rate in Japanese outpatients. PEDF may play some role in sympathetic nerve activity.
AB - We have recently found that serum level of pigment epithelium derived factor (PEDF) is significantly increased in proportion to the accumulation of the number of the components of the metabolic syndrome. Although high heart rate is also associated with metabolic risk factors for atherosclerosis, the correlation between serum level of PEDF and resting heart rate remains to be elucidated. In this study, we examined their relationship in Japanese outpatients. Four hundred two consecutive outpatients at Nakamura Clinic (141 male and 261 female; mean age 74.9 ± 9.9) underwent a complete history and physical examination, determination of blood chemistries and PEDF levels. In multiple regression analysis, smoking (p = 0.003), use of β-blockers (p = 0.010, inversely), presence of atrial fibrillation (p = 0.014), PEDF (p = 0.018) and glucose levels (p = 0.033) were independently correlated to resting heart rate. Further, when mean serum PEDF levels were stratified by resting heart rates, a linear and significant trend (p = 0.025) was observed. The present study demonstrated for the first time that serum level of PEDF was one of the independent determinants of resting heart rate in Japanese outpatients. PEDF may play some role in sympathetic nerve activity.
KW - Cardiovascular disease
KW - PEDF
KW - Resting heart rate
UR - http://www.scopus.com/inward/record.url?scp=67650766630&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650766630&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2008.04.055
DO - 10.1016/j.ijcard.2008.04.055
M3 - Article
VL - 136
SP - 245
EP - 247
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -