Serum levels of IFN-inducible protein-10 relating to the activity of systemic lupus erythematosus

Shosaku Narumi, Tsutomu Takeuchi, Yuko Kobayashi, Konosuke Konishi

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

IFN-inducible protein-10 (IP-10) is supposed to act as a specific chemoattractant for Th1 cells. Since Th1 cells and IFN-γ are shown to be important for developing systemic lupus erythematosus (SLE), we examined the relationship between serum IP-10 levels and the disease activity. Serum IP-10 levels were markedly increased in the SLE patients depending on the level of disease activity, whereas not in the patients with rheumatoid arthritis (RA). On the other hand, serum MCP-1 levels were increased to a similar extent both in RA and inactive SLE patients, and a little more elevated in active SLE patients. Serum IP-10 levels in SLE patients correlated positively and negatively with levels of anti-DNA antibody and complements, respectively, whereas MCP-1 levels correlated less or not at all. These results suggest that serum IP-10 levels could be a good indicator for the activity of SLE and that IP-10 could play an important immunological role in SLE. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)1561-1565
Number of pages5
JournalCytokine
Volume12
Issue number10
DOIs
Publication statusPublished - 2000

Keywords

  • Chemokine
  • ELISA
  • IP-10
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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